Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.41 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1096216 | 0.81 | TSHR (0.56) | TSHRCYP2A6CYP1A2HSD17B10ALDH1A1 | |
| SCHEMBL607363 | 0.81 | TSHR (0.56) | TSHRCYP2A6CYP1A2HSD17B10ALDH1A1 | |
| SCHEMBL6547337 | 0.80 | TSHR (0.50) | TSHRCYP2A6CYP1A2HSD17B10ALDH1A1 | |
| SCHEMBL6244662 | 0.79 | CYP2A6 (0.54) | TSHRCYP2A6CYP1A2HSD17B10ALDH1A1 | |
| SCHEMBL17956320 | 0.79 | TSHR (0.54) | TSHRCYP2A6CYP1A2HSD17B10ALDH1A1 | |
| SCHEMBL13065801 | 0.79 | TSHR (0.54) | TSHRCYP2A6CYP1A2HSD17B10ALDH1A1 | |
| SCHEMBL6445510 | 0.79 | TSHR (0.54) | TSHRCYP2A6CYP1A2HSD17B10ALDH1A1 | |
| SCHEMBL30066580 | 0.78 | ALDH1A1 (0.48) | TSHRCYP2A6CYP1A2HSD17B10ALDH1A1 | |
| SCHEMBL5691676 | 0.78 | ALDH1A1 (0.48) | TSHRCYP2A6CYP1A2HSD17B10ALDH1A1 | |
| SCHEMBL5252480 | 0.78 | TSHR (0.52) | TSHRCYP2A6CYP1A2HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180118860-A1 | Supported Catalyst Systems and Processes for Use Thereof | EXXONMOBIL CHEMICAL PATENTS INC. | 2018-05-03 | — | — | US | disclosed |
| US-20180086859-A1 | Supported Catalyst Systems and Processes for Use Thereof | EXXONMOBIL CHEMICAL PATENTS INC. | 2018-03-29 | — | — | US | disclosed |
| US-20180079845-A1 | Multimodal and Broad Molecular Weight High Density Polyethylene | EXXONMOBIL CHEMICAL PATENTS INC. | 2018-03-22 | — | — | US | disclosed |
| US-9102773-B2 | Process for controlling molecular weight of polyolefins prepared using pyridyl diamide catalyst systems | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2015-08-11 | — | — | US | disclosed |
| US-9067905-B2 | Sulphone compounds and methods of making and using same | ZAFGEN, INC. (US) | 2015-06-30 | — | — | US | disclosed |
| US-20140221587-A1 | Process for Controlling Molecular Weight of Polyolefins Prepared Using Pyridyl Diamide Catalyst Systems | EXXONMOBIL CHEMICAL PATENTS INC. | 2014-08-07 | — | — | US | disclosed |
| US-8710163-B2 | Pyridyldiamido transition metal complexes, production and use thereof | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2014-04-29 | — | — | US | disclosed |
| US-8674040-B2 | Pyridyldiamido transition metal complexes, production and use thereof | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2014-03-18 | — | — | US | disclosed |
| US-8394902-B2 | Pyridyldiamido transition metal complexes, production and use thereof | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2013-03-12 | — | — | US | disclosed |
| US-20130053364-A1 | Sulphone Compounds and Methods of Making and Using Same | ZAFGEN, INC. | 2013-02-28 | — | — | US | disclosed |
| EP-2486004-A2 | SULPHONE COMPOUNDS AND METHODS OF MAKING AND USING SAME | Zafgen Corporation (US) | 2012-08-15 | — | — | EP | disclosed |
| US-20120094982-A1 | 1,4-BENZODIAZEPINONE COMPOUNDS AND THEIR USE IN TREATING CANCER | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-04-19 | — | — | US | disclosed |
| US-20120071616-A1 | Pyridyldiamido Transition Metal Complexes, Production And Use Thereof | EXXONMOBIL CHEMICAL PATENTS INC. | 2012-03-22 | — | — | US | disclosed |
| US-20110301310-A1 | Pyridyldiamido Transition Metal Complexes, Production And Use Thereof | EXXONMOBIL CHEMICAL PATENTS INC. | 2011-12-08 | — | — | US | disclosed |
| US-20110224391-A1 | Pyridyldiamido Transition Metal Complexes, Production and Use Thereof | EXXONMOBIL CHEMICAL PATENTS INC. | 2011-09-15 | — | — | US | disclosed |
| WO-2011044506-A2 | SULPHONE COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN CORPORATION (US) | 2011-04-14 | — | — | WO | disclosed |
| EP-0393941-A1 | Naphthalene derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-10-24 | — | — | EP | disclosed |
| US-4897405-A | Novel naphthalenylalkyl-3H-1,2,3,5-oxathiadiazole 2-oxides useful as antihyperglycemic agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180086859-A1 | Supported Catalyst Systems and Processes for Use Thereof | PARG, PUF60, SCO2 | TSHR 4771/4885CYP2A6 3268/4885CYP1A2 2409/4885 |
| US-20120094982-A1 | 1,4-BENZODIAZEPINONE COMPOUNDS AND THEIR USE IN TREATING CANCER | HTR4, HTR1A, HTR3B | TSHR 2595/4885CYP2A6 174/4885CYP1A2 98/4885 |
| US-20110301310-A1 | Pyridyldiamido Transition Metal Complexes, Production And Use Thereof | PNPO, PLPBP, PDXK | TSHR 4158/4885CYP2A6 1415/4885CYP1A2 724/4885 |
| US-20110224391-A1 | Pyridyldiamido Transition Metal Complexes, Production and Use Thereof | PICALM, PARN, PCBP1 | TSHR 4582/4885CYP2A6 2934/4885CYP1A2 2370/4885 |
| US-20120071616-A1 | Pyridyldiamido Transition Metal Complexes, Production And Use Thereof | PNPO, PLPBP, PDXK | TSHR 4158/4885CYP2A6 1415/4885CYP1A2 724/4885 |
| US-20130053364-A1 | Sulphone Compounds and Methods of Making and Using Same | METAP2, DNPEP, STS | TSHR 3569/4885CYP2A6 284/4885CYP1A2 300/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.