Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 3/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | ALPL | P05186 | 1/20 | 0.30 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9231998 | 0.74 | PGR (0.52) | KMT2AMEN1PGRCA1CA2 | |
| SCHEMBL18890215 | 0.73 | KEAP1 (0.53) | KMT2AMEN1POLBPGRCA1 | |
| SCHEMBL28468894 | 0.73 | CA2 (0.45) | KMT2AMEN1CA1CA2CA9 | |
| SCHEMBL4565158 | 0.67 | PGR (0.50) | KMT2AMEN1POLBPGRCA1 | |
| SCHEMBL3655891 | 0.66 | HTR6 (0.54) | CA1CA2CA9ALDH1A1HSD17B10 | |
| SCHEMBL2850012 | 0.66 | DAO (0.37) | POLBCA2MCL1ALDH1A1HSD17B10 | |
| SCHEMBL8585871 | 0.66 | MEN1 (0.41) | KMT2AMEN1POLBCA1CA2 | |
| SCHEMBL22928235 | 0.66 | MAPT (0.44) | KMT2AMEN1POLBALDH1A1MAPK1 | |
| SCHEMBL7995667 | 0.66 | CCR2 (0.38) | POLBPGRCA1CA2CA9 | |
| SCHEMBL4869139 | 0.66 | PGR (0.60) | KMT2APOLBPGRCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331637-B1 | N-Alkyl, N-Alkenyl, N-Alkynyl, N-Aryl and N-fused bicyclo or tricyclo thienyl-, furyl-,and Pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin | TEXAS BIOTECHNOLOGY CORPORATION | 2001-12-18 | — | — | US | disclosed |