Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 3/20 | 0.59 |
| ▸ | SYK | P43405 | 8/20 | 0.43 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.42 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.42 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.41 |
| ▸ | INCENP | Q9NQS7 | 3/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 3/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.36 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7984832 | 0.85 | PTGES (0.63) | PTGESBRD4KCNA3 | |
| SCHEMBL7996575 | 0.83 | PTGES (0.55) | PTGESBRD4PRKDCABCB1PIK3CD | |
| SCHEMBL7994940 | 0.80 | PTGES (0.52) | PTGESBRD4PRKDCHTR1ADRD2 | |
| SCHEMBL7996440 | 0.80 | PTGES (0.54) | PTGESPIK3CD | |
| SCHEMBL7984763 | 0.80 | PTGES (0.54) | PTGESKCNA3 | |
| SCHEMBL7996719 | 0.79 | PTGES (0.64) | PTGES | |
| SCHEMBL7984591 | 0.77 | PTGES (0.61) | PTGES | |
| SCHEMBL23876437 | 0.74 | PTGES (1.00) | PTGESHTR1A | |
| Trifluoroacetic Acid SCHEMBL7996801 | 0.73 | PTGES (0.52) | PTGESSYKBRD4PRKDCHTR1A | |
| SCHEMBL7994951 | 0.73 | PTGES (0.56) | PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001079209-A2 | DIAZAFLUORENONE IL-8 ANTAGONISTS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2001-10-25 | — | — | WO | claimed |
| WO-2001079209-A2 | DIAZAFLUORENONE IL-8 ANTAGONISTS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2001-10-25 | — | — | WO | disclosed |