Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 3/20 | 0.42 |
| ▸ | USP8 | P40818 | 4/20 | 0.40 |
| ▸ | USP7 | Q93009 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7994925 | 0.82 | PTGES (0.40) | PTGESKMT2APOLBLMNAMAPT | |
| SCHEMBL7996571 | 0.81 | USP8 (0.59) | PTGESUSP8USP7KMT2APOLB | |
| SCHEMBL7984773 | 0.80 | PTGES (0.41) | PTGESUSP8USP7KMT2ALMNA | |
| SCHEMBL7984866 | 0.77 | PTGES (0.39) | PTGESKMT2APOLBLMNAMAPT | |
| SCHEMBL7996719 | 0.76 | PTGES (0.64) | PTGESUSP8USP7KMT2ALMNA | |
| SCHEMBL7998545 | 0.75 | USP8 (0.59) | PTGESUSP8USP7KMT2APOLB | |
| SCHEMBL7984632 | 0.68 | USP8 (0.60) | PTGESUSP8USP7KMT2ALMNA | |
| SCHEMBL7984594 | 0.63 | PTGES (0.49) | PTGESUSP8USP7KMT2ALMNA | |
| SCHEMBL7983849 | 0.62 | PTGES (0.57) | PTGESUSP8KMT2APOLBLMNA | |
| SCHEMBL7998365 | 0.60 | USP7 (0.59) | PTGESUSP8USP7KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001079209-A2 | DIAZAFLUORENONE IL-8 ANTAGONISTS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2001-10-25 | — | — | WO | claimed |
| WO-2001079209-A2 | DIAZAFLUORENONE IL-8 ANTAGONISTS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2001-10-25 | — | — | WO | disclosed |