Sugi Predict

Sugi Predict / Compounds / SCHEMBL7999562

SCHEMBL7999562

SCHEMBL7999562

O=Cc1ccc(OC(F)F)nc1

nearest known ligand 0.54

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 3/20 0.54
▸ L3MBTL1 Q9Y468 2/20 0.54
▸ KDM4E B2RXH2 4/20 0.50
▸ DRD1 P21728 3/20 0.49
▸ POLB P06746 1/20 0.46
▸ DAO P14920 1/20 0.43
▸ NPC1 O15118 1/20 0.39
▸ ALDH1A3 P47895 1/20 0.36
▸ KCNJ1 P48048 1/20 0.36
▸ FDPS P14324 1/20 0.35
▸ HCRTR1 O43613 2/20 0.34
▸ HCRTR2 O43614 2/20 0.34
▸ LMNA P02545 1/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.33
▸ ACACB O00763 1/20 0.33
▸ ACACA Q13085 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29416918 1.00 ALDH1A1 (0.54) ALDH1A1L3MBTL1KDM4EDRD1POLB
SCHEMBL29005200 0.81 DAO (0.40) ALDH1A1L3MBTL1KDM4EDRD1POLB
SCHEMBL1943602 0.81 KDM4E (0.54) ALDH1A1L3MBTL1KDM4EPOLBALDH1A3
SCHEMBL29935624 0.81 KDM4E (0.54) ALDH1A1L3MBTL1KDM4EPOLBALDH1A3
SCHEMBL29417077 0.80 ALDH1A1 (0.53) ALDH1A1L3MBTL1KDM4EDRD1POLB
SCHEMBL20489914 0.80 ALDH1A1 (0.53) ALDH1A1L3MBTL1KDM4EDRD1POLB
SCHEMBL15941772 0.77 P4HTM (0.54) ALDH1A1KDM4EPOLBNPC1LMNA
SCHEMBL15941773 0.77 P4HTM (0.54) ALDH1A1KDM4EPOLBNPC1LMNA
SCHEMBL8567940 0.77 ALDH1A1 (0.57) ALDH1A1L3MBTL1KDM4EDRD1POLB
SCHEMBL7808516 0.75 L3MBTL1 (0.48) ALDH1A1L3MBTL1KDM4EDRD1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 92 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12509439-B2 Anti-malarial agents UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) 2025-12-30 — — US disclosed
US-12497399-B2 Fluorinated integrin antagonists OCUTERRA THERAPEUTICS, INC. (US) 2025-12-16 — — US disclosed
US-12286432-B2 Fluorinated tetrahydronaphthyridinyl nonanoic acid derivatives and uses thereof OCUTERRA THERAPEUTICS, INC. (US) 2025-04-29 — — US disclosed
CN-114163437-B Substituted pyrazolo [1,5-a ] pyridine compounds as RET kinase inhibitors 阿雷生物药品公司 2025-03-04 — — CN disclosed
CN-115380027-B Novel antimalarial agents 肯塔基大学研究基金会 2024-10-18 — — CN disclosed
WO-2024134541-A1 HETEROCYCLIC COMPOUNDS AS ENT INHIBITORS AND COMPOUNDS FOR USE IN THE TREATMENT OF CANCERS iTeos Belgium SA (BE) 2024-06-27 — — WO disclosed
US-11998545-B2 Substituted pyrazolo[1,5-a]pyridine compounds as RET kinase inhibitors ARRAY BIOPHARMA INC. (US) 2024-06-04 — — US disclosed
US-20240140942-A1 FLUORINATED INTEGRIN ANTAGONISTS FELIQS CORPORATION (JP) 2024-05-02 — — US disclosed
US-20240092775-A1 FLUORINATED TETRAHYDRONAPHTHYRIDINYL NONANOIC ACID DERIVATIVES AND USES THEREOF FELIQS CORPORATION (JP) 2024-03-21 — — US disclosed
US-20240066029-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2024-02-29 — — US disclosed
US-6022967-A 1-NITRO-2-CARBOXYVINYL- OR 1-NITRO-2-(DIMETHYLAMINO)VINYL-SUBSTITUTED IMIDAZOLIDINES OR TETRAHYDROPYRIMIDINES NIHON BAYER AGROCHEM K.K. (JP) 2000-02-08 — — US disclosed
US-5580889-A Insecticidal nitromethyl or niteoimino-heteromethyl-heterocyclics NIHON BAYER AGROCHEM K.K. (JP) 1996-12-03 — — US disclosed
US-5461167-A 2-chloro-5-chloromethyl thiazole; insecticide NIHON BAYER AGROCHEM K.K. (JP) 1995-10-24 — — US disclosed
US-5428032-A Insecticides NIHON BAYER AGROCHEM K.K. (JP) 1995-06-27 — — US disclosed
US-5298507-A Insecticides NIHON BAYER AGROCHEM K.K. (JP) 1994-03-29 — — US disclosed
US-5204360-A Insecticides NIHON BAYER AGROCHEM K.K. (JP) 1993-04-20 — — US disclosed
US-5001138-A Insecticides NIHON TOKUSHU NOYAKU SEIZO, K.K. (JP) 1991-03-19 — — US disclosed
US-4845106-A INSECTICIDES NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1989-07-04 — — US disclosed
US-4742060-A 2-(NITROIMINO)- OR 2-(NITROMETHYLENE)-IMIDAZOLIDINES AS INSECTICIDES NIHON TOKUSHU NOYAKU SEIZO K. K. (JP) 1988-05-03 — — US disclosed
EP-0192060-A1 Heterocyclic compounds NIHON BAYER AGROCHEM K.K. (JP) 1986-08-27 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240092775-A1 FLUORINATED TETRAHYDRONAPHTHYRIDINYL NONANOIC ACID DERIVATIVES AND USES THEREOF FFAR3, FFAR2, FFAR1 ALDH1A1 1949/4885L3MBTL1 4681/4885KDM4E 4044/4885
US-20240140942-A1 FLUORINATED INTEGRIN ANTAGONISTS ITGB5, ITGB1, ITGA5 ALDH1A1 2260/4885L3MBTL1 4764/4885KDM4E 2577/4885
US-12509439-B2 Anti-malarial agents RCC1, PFN1, NHERF1 ALDH1A1 1353/4885L3MBTL1 3793/4885KDM4E 3704/4885
US-12286432-B2 Fluorinated tetrahydronaphthyridinyl nonanoic acid derivatives and uses thereof FFAR3, FFAR2, FFAR1 ALDH1A1 1949/4885L3MBTL1 4681/4885KDM4E 4044/4885
US-12497399-B2 Fluorinated integrin antagonists ITGB5, ITGB1, ITGA5 ALDH1A1 2260/4885L3MBTL1 4764/4885KDM4E 2577/4885
US-11998545-B2 Substituted pyrazolo[1,5-a]pyridine compounds as RET kinase inhibitors RET, ROR1, BRAF ALDH1A1 2868/4885L3MBTL1 1445/4885KDM4E 889/4885
US-20240066029-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, ROR1, BRAF ALDH1A1 2868/4885L3MBTL1 1445/4885KDM4E 889/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.