Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 9/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 9/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 8/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 8/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 8/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 8/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | GABRA6 | Q16445 | 6/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | GABRE | P78334 | 1/20 | 0.33 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.33 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.33 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL164417 | 0.79 | HPGDS (0.35) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL28575317 | 0.78 | FBP1 (0.53) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL25014083 | 0.74 | FBP1 (0.36) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL11035430 | 0.74 | GABRG2 (0.33) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL30424999 | 0.72 | ALDH1A1 (0.59) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL20352133 | 0.69 | ATR (0.42) | HDAC1DAGLAMEN1GAAKMT2A | |
| SCHEMBL30177496 | 0.67 | GABRG2 (0.35) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL5500301 | 0.67 | MAPT (0.44) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL11034443 | 0.66 | L3MBTL1 (0.40) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL3583659 | 0.66 | C3AR1 (0.35) | LMNAHDAC1HDAC8HDAC6FBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518928-B2 | Therapeutic compounds | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2013-08-27 | — | — | US | disclosed |
| US-20120071527-A1 | THERAPEUTIC COMPOUNDS | UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY (US) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071527-A1 | THERAPEUTIC COMPOUNDS | TOP2B, DDB1, TOP1 | GABRG2 4300/4885GABRB3 3528/4885GABRA5 4632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.