Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP14 | P50281 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.33 |
| ▸ | PYGL | P06737 | 1/20 | 0.32 |
| ▸ | PYGM | P11217 | 1/20 | 0.32 |
| ▸ | CCKAR | P32238 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | DRD3 | P35462 | 2/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD5 | P21918 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.32 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.32 |
| ▸ | STAT6 | P42226 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4058066 | 0.87 | MMP2 (0.36) | MMP2MMP14MCHR1ESR1DRD2 | |
| SCHEMBL7995568 | 0.84 | DRD2 (0.34) | MCHR1ESR1DRD2CYP51A1PYGL | |
| SCHEMBL7995086 | 0.79 | TAS1R3 (0.41) | DRD2DRD3TRPV4TAS1R3TAS1R1 | |
| SCHEMBL7989864 | 0.78 | PYGL (0.37) | DRD2CYP51A1PYGLPYGMDRD3 | |
| SCHEMBL4059766 | 0.78 | DRD2 (0.37) | MMP2MMP14DRD2CYP51A1CCKAR | |
| SCHEMBL8010544 | 0.78 | TRPV4 (0.52) | TRPV4STAT6TAS1R3TAS1R1 | |
| SCHEMBL8004923 | 0.77 | PYGL (0.37) | DRD2CYP51A1PYGLDRD3BCAT1 | |
| SCHEMBL7995048 | 0.77 | DRD2 (0.43) | DRD2CYP51A1PYGLGAASTAT6 | |
| SCHEMBL7996360 | 0.76 | SMYD3 (0.36) | MCHR1DRD2CYP51A1PYGLPYGM | |
| SCHEMBL7996254 | 0.76 | STAT6 (0.37) | CYP51A1PYGLDRD3STAT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | disclosed |