Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CCKBR | P32239 | 3/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PYGL | P06737 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | STAT6 | P42226 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8004923 | 0.82 | PYGL (0.37) | DRD2CYP51A1PYGL | |
| SCHEMBL7998609 | 0.81 | DRD2 (0.47) | DRD2KDM4EGAACYP51A1ALDH1A1 | |
| SCHEMBL7989861 | 0.81 | DRD2 (0.47) | DRD2KDM4EGAACYP51A1ALDH1A1 | |
| SCHEMBL7995568 | 0.80 | DRD2 (0.34) | DRD2CYP51A1ALDH1A1CCKBRPYGL | |
| SCHEMBL8002722 | 0.79 | STAT6 (0.35) | DRD2CYP51A1ALDH1A1CCKBRPYGL | |
| SCHEMBL7989864 | 0.78 | PYGL (0.37) | DRD2CYP51A1PYGL | |
| SCHEMBL8002404 | 0.78 | PYGL (0.37) | DRD2KDM4ECYP51A1ALDH1A1PYGL | |
| SCHEMBL8004750 | 0.77 | MMP2 (0.33) | DRD2GAACYP51A1TAS1R3TAS1R1 | |
| SCHEMBL8004714 | 0.76 | ALOX15 (0.40) | CYP51A1PYGL | |
| SCHEMBL8002402 | 0.76 | STAT6 (0.37) | CYP51A1ALDH1A1CCKBRPYGLSTAT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | disclosed |