Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
| ▸ | TDP2 | O95551 | 1/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | GALK1 | P51570 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.37 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.37 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL186752 | 0.85 | LMNA (0.51) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL15628330 | 0.83 | L3MBTL1 (0.35) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL15731795 | 0.81 | PIK3R1 (0.39) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL17576245 | 0.80 | AKR1C3 (0.44) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL29483984 | 0.80 | RAD51 (0.51) | MAPTMEN1KMT2APRKDCTSHR | |
| SCHEMBL1919863 | 0.80 | AKR1C3 (0.44) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL20050092 | 0.80 | ALDH1A1 (0.42) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL6330031 | 0.80 | KMT2A (0.49) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL20694863 | 0.79 | GSK3B (0.39) | EP300KAT2BRAD51 | |
| SCHEMBL18028120 | 0.79 | ALDH1A1 (0.42) | MAPTMEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7579472-B2 | Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-08-25 | — | — | US | disclosed |
| US-7579472-B2 | Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-08-25 | — | — | US | disclosed |
| US-7435821-B2 | Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-10-14 | — | — | US | disclosed |
| US-7435821-B2 | Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-10-14 | — | — | US | disclosed |
| US-20080009626-A1 | Reacting a 3-leaving group-1-(p-leaving group-phenyl)tetrahydro-2-pyridone with 2-hydroxypyridine and reacting the product with an alpha-oxoacetaldehyde phenylhydrazone to form 1-phenyl-3-carbonyl-6-(p-(2-pyridon-1-yl)phenyl-4,5-dihydro-pyrazolo[3,4-c]pyrid-2-one derivatives; bases; aprotic solvents | MUDRYK BOGUSLAW M | 2008-01-10 | — | — | US | disclosed |
| US-20080009626-A1 | Reacting a 3-leaving group-1-(p-leaving group-phenyl)tetrahydro-2-pyridone with 2-hydroxypyridine and reacting the product with an alpha-oxoacetaldehyde phenylhydrazone to form 1-phenyl-3-carbonyl-6-(p-(2-pyridon-1-yl)phenyl-4,5-dihydro-pyrazolo[3,4-c]pyrid-2-one derivatives; bases; aprotic solvents | MUDRYK BOGUSLAW M | 2008-01-10 | — | — | US | disclosed |
| US-20070282106-A1 | EFFICIENT SYNTHESIS OF 4,5-DIHYDRO-PYRAZOLO[3,4-c]PYRID-2-ONES | MUDRYK BOGUSLAW M | 2007-12-06 | — | — | US | disclosed |
| US-20070282106-A1 | EFFICIENT SYNTHESIS OF 4,5-DIHYDRO-PYRAZOLO[3,4-c]PYRID-2-ONES | MUDRYK BOGUSLAW M | 2007-12-06 | — | — | US | disclosed |
| US-7304157-B2 | Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-12-04 | — | — | US | disclosed |
| US-7304157-B2 | Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-12-04 | — | — | US | disclosed |
| US-20060069119-A1 | Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones | BRISTOL-MYERS SQUIBB COMPANY | 2006-03-30 | — | — | US | disclosed |
| US-20060069119-A1 | Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones | BRISTOL-MYERS SQUIBB COMPANY | 2006-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070282106-A1 | EFFICIENT SYNTHESIS OF 4,5-DIHYDRO-PYRAZOLO[3,4-c]PYRID-2-ONES | F2, TFPI, PDXK | MAPT 4428/4885MEN1 2460/4885KMT2A 1842/4885 |
| US-20060069119-A1 | Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones | F2, TFPI, PDXK | MAPT 4428/4885MEN1 2460/4885KMT2A 1842/4885 |
| US-20080009626-A1 | Reacting a 3-leaving group-1-(p-leaving group-phenyl)tetrahydro-2-pyridone with 2-hydroxypyridine and reacting the product with an alpha-oxoacetaldehyde phenylhydrazone to form 1-phenyl-3-carbonyl-6-(p-(2-pyridon-1-yl)phenyl-4,5-dihydro-pyrazolo[3,4-c]pyrid-2-one derivatives; bases; aprotic solvents | PDXK, PLPBP, PNPO | MAPT 4559/4885MEN1 2165/4885KMT2A 2357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.