Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 5/20 | 0.39 |
| ▸ | RXRA | P19793 | 3/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.36 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | VNN1 | O95497 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.33 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.33 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.33 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4305907 | 0.88 | LMNA (0.38) | GRIN2BRXRAGRIN1MAPTTAS1R3 | |
| SCHEMBL4311981 | 0.72 | LMNA (0.44) | MAPTTAS1R3TAS1R1TAS1R2LMNA | |
| SCHEMBL78909 | 0.70 | KIF11 (0.60) | GRIN2BRXRAGRIN1KIF11TAS1R3 | |
| SCHEMBL29421493 | 0.70 | KIF11 (0.60) | GRIN2BRXRAGRIN1KIF11TAS1R3 | |
| SCHEMBL14012598 | 0.70 | KIF11 (0.60) | GRIN2BRXRAGRIN1KIF11TAS1R3 | |
| SCHEMBL4301396 | 0.70 | KMT2A (0.43) | MAPTTAS1R3TAS1R1POLB | |
| SCHEMBL2074095 | 0.69 | TAS1R3 (0.49) | MAPTKIF11TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL5430185 | 0.68 | TAS1R3 (0.47) | KIF11TAS1R3TAS1R1TAS1R2HDAC8 | |
| SCHEMBL31073539 | 0.67 | HPGD (0.50) | MAPTTAS1R3TAS1R1TAS1R2HDAC8 | |
| SCHEMBL20716307 | 0.67 | VNN1 (0.43) | TAS1R3TAS1R1TAS1R2HDAC8VNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009130231-A1 | PYRROLO [1, 2-A] PYRAZINE DERIVATIVES AS VASOPRESSIN VIB RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-10-29 | — | — | WO | disclosed |