Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8709054 | 0.82 | CYP3A4 (0.47) | ALDH1A1MAPTKDM4ETSHRCYP2C19 | |
| SCHEMBL8024858 | 0.82 | ALDH1A1 (0.39) | NPC1KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL8020333 | 0.79 | XDH (0.45) | NPC1ALDH1A1RAB9ACASP3SENP8 | |
| SCHEMBL7361925 | 0.77 | TDP1 (0.49) | TDP1NPC1KMT2AMEN1ALDH1A1 | |
| SCHEMBL8027078 | 0.77 | TLR7 (0.50) | TDP1NPC1KMT2AMEN1ALDH1A1 | |
| SCHEMBL8021145 | 0.76 | KDM4E (0.40) | NPC1KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL8715277 | 0.75 | CLCN2 (0.38) | KMT2AMEN1ALDH1A1MAPTRAB9A | |
| SCHEMBL8709579 | 0.75 | KDM4E (0.38) | KMT2AMEN1ALDH1A1MAPTRAB9A | |
| SCHEMBL8710246 | 0.75 | XDH (0.40) | NPC1ALDH1A1MAPTRAB9ACASP3 | |
| SCHEMBL7364613 | 0.74 | TDP1 (0.49) | TDP1NPC1KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0802187-B1 | Hydroxypyridine derivatives, their production and their pharmaceutical use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2000-02-16 | — | — | EP | disclosed |
| US-5891895-A | POTASSIUM CHANNEL MODULATORS; ANGINA PECTORIS; HYPERTENSIVEAGENTS; CARDIOVASCULAR, RESPIRATORY SYSTEM, BRAIN, GASTROINTESTINAL AND UROGENITAL DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-04-06 | — | — | US | disclosed |
| EP-0802187-A1 | Hydroxypyridine derivatives, their production and their pharmaceutical use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-10-22 | — | — | EP | disclosed |