Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 18/20 | 0.95 |
| ▸ | CA1 | P00915 | 17/20 | 0.95 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8029235 | 0.95 | CA2 (1.00) | CA2CA1CA4MAPT | |
| Terephthalic Acid SCHEMBL31095057 | 0.80 | CA2 (0.68) | CA2CA1CA4MAPT | |
| Terephthalic Acid SCHEMBL107909 | 0.80 | CA2 (0.68) | CA2CA1CA4MAPT | |
| SCHEMBL1559089 | 0.78 | CA1 (0.67) | CA2CA1MAPT | |
| Potassium Ion SCHEMBL6911291 | 0.77 | ALDH1A1 (0.61) | CA2CA1MAPT | |
| Terephthalic Acid SCHEMBL15641843 | 0.77 | CA2 (0.74) | CA2CA1CA4MAPT | |
| Terephthalic Acid SCHEMBL7910695 | 0.77 | CA2 (0.65) | CA2CA1CA4MAPT | |
| Terephthalic Acid SCHEMBL9930546 | 0.77 | CA2 (0.65) | CA2CA1CA4MAPT | |
| SCHEMBL13683319 | 0.76 | CA1 (0.64) | CA2CA1MAPT | |
| SCHEMBL40281 | 0.76 | CA1 (0.64) | CA2CA1CA4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779318-B1 | Silicon-containing block copolymer | WAKO PURE CHEMICAL INDUSTIES L (JP) | 2000-02-16 | — | — | EP | disclosed |
| US-5760136-A | FORMING AN ADDITION-CONDENSATION COPOLYMER BY POLYMERIZING AN AZO-CONTAINING POLYSILOXANE AND AN UNSATURATED MONOMER; CATIONIC AND NONIONIC POLYMERS; POLYAMPHOLYTES; COATINGS; ADHESIVES; PAINTS; HAIR COSMETICS | WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) | 1998-06-02 | — | — | US | disclosed |
| EP-0779318-A1 | Silicon-containing block copolymer | Wako Pure Chemical Industries, Ltd. (JP) | 1997-06-18 | — | — | EP | disclosed |