Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 7/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 3/20 | 0.36 |
| ▸ | DRD3 | P35462 | 7/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 6/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8024325 | 0.72 | MAOA (0.43) | MAOA | |
| SCHEMBL8031762 | 0.71 | MAOA (0.37) | HTR2AHTR2CMAOA | |
| SCHEMBL1009954 | 0.71 | HTR2B (0.50) | HTR2AHTR2CHTR2BSLC6A2SLC6A4 | |
| SCHEMBL8030277 | 0.70 | MAOA (0.54) | SLC6A2SLC6A4SLC6A3MAOADRD2 | |
| SCHEMBL8029047 | 0.70 | HTR1A (0.43) | MAOAHTR1ADRD2 | |
| SCHEMBL8015297 | 0.70 | DRD3 (0.36) | MAOADRD3DRD2CHRNB2CHRNA4 | |
| SCHEMBL8022070 | 0.69 | MAOA (0.41) | SLC6A2SLC6A4SLC6A3MAOAHTR1A | |
| SCHEMBL7978723 | 0.68 | GID4 (0.44) | HTR2ASLC6A2SLC6A4SLC6A3MAOA | |
| SCHEMBL8028688 | 0.68 | ADRA2A (0.50) | HTR2CMAOAHTR1ADRD2 | |
| SCHEMBL8027387 | 0.68 | GID4 (0.44) | MAOADRD3HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |