Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.56 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CA9 | Q16790 | 3/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA5A | P35218 | 1/20 | 0.47 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | UBE2M | P61081 | 1/20 | 0.41 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8050817 | 0.90 | PTGS2 (0.57) | PTGS2CA1CA2CA9CA12 | |
| SCHEMBL8044812 | 0.86 | ALDH1A1 (0.52) | MEN1MAPTHTTRAB9AKMT2A | |
| SCHEMBL8034180 | 0.86 | MAPT (0.49) | PTGS2MEN1MAPTHTTKMT2A | |
| SCHEMBL8043931 | 0.84 | PTGS2 (0.43) | PTGS2CA1CA2CA9CA12 | |
| SCHEMBL8046294 | 0.83 | UBE2M (0.45) | MAPTHTTRAB9AKMT2AUBE2M | |
| SCHEMBL8045514 | 0.83 | HPGD (0.54) | MEN1MAPTHTTRAB9AKMT2A | |
| SCHEMBL8032472 | 0.82 | PTGS2 (0.48) | PTGS2CA1CA2CA9CA12 | |
| SCHEMBL8042528 | 0.81 | ALDH1A1 (0.45) | MAPTHTTRAB9AKMT2AUBE2M | |
| SCHEMBL8042159 | 0.81 | RAB9A (0.47) | PTGS2MEN1MAPTHTTRAB9A | |
| SCHEMBL8044654 | 0.81 | MAPT (0.44) | PTGS2MEN1MAPTHTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |