Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | ALPG | P10696 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8047351 | 0.82 | KMT2A (0.47) | TSHRLMNAMAPK1HTTRAB9A | |
| SCHEMBL8050306 | 0.82 | LMNA (0.41) | TSHRLMNAMAPK1SMN1; SMN2HTT | |
| SCHEMBL8051539 | 0.80 | L3MBTL1 (0.40) | TSHRLMNAMAPK1SMN1; SMN2HTT | |
| SCHEMBL8045832 | 0.80 | LMNA (0.42) | TSHRLMNAMAPK1SMN1; SMN2HTT | |
| SCHEMBL8043765 | 0.80 | L3MBTL1 (0.41) | TSHRLMNAMAPK1SMN1; SMN2HTT | |
| SCHEMBL8032361 | 0.79 | ALDH1A1 (0.47) | LMNASMN1; SMN2HTTNPC1TP53 | |
| SCHEMBL8033852 | 0.79 | ALDH1A1 (0.39) | TSHRLMNAMAPK1SMN1; SMN2HTT | |
| SCHEMBL8043601 | 0.79 | ALDH1A1 (0.37) | TSHRLMNAMAPK1SMN1; SMN2HTT | |
| SCHEMBL8048145 | 0.78 | ALDH1A1 (0.55) | TSHRLMNAMAPK1SMN1; SMN2HTT | |
| SCHEMBL8713674 | 0.77 | LMNA (0.40) | TSHRLMNAMAPK1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |