Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF4E | P06730 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.33 |
| ▸ | MEN1 | O00255 | 5/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 4/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | MITF | O75030 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALPG | P10696 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8049863 | 0.85 | MAPT (0.43) | EIF4EKMT2AMEN1POLBHPGD | |
| SCHEMBL8043331 | 0.84 | MAPT (0.34) | EIF4EKMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL8032798 | 0.84 | KDM4E (0.32) | EIF4EMAPTHTT | |
| SCHEMBL8045804 | 0.83 | KDM1A (0.39) | EIF4EKMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL8044497 | 0.80 | HTT (0.33) | EIF4EKMT2AMEN1POLBMAPT | |
| SCHEMBL8047853 | 0.78 | KMT2A (0.40) | KMT2AMEN1POLBHPGDSMN1; SMN2 | |
| SCHEMBL8041803 | 0.78 | MAPT (0.34) | KMT2AMEN1LMNACYP1A2CYP3A4 | |
| SCHEMBL8043200 | 0.78 | ALDH1A1 (0.43) | KMT2APOLBHPGDSMN1; SMN2LMNA | |
| SCHEMBL8043931 | 0.76 | PTGS2 (0.43) | CYP2C9 | |
| SCHEMBL8033936 | 0.76 | ALDH1A1 (0.42) | KMT2AMEN1POLBHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |