Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | RORB | Q92753 | 1/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | EIF4E | P06730 | 1/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8046557 | 0.87 | CTSS (0.35) | F2RL3ALDH1A1L3MBTL1MAPTHSD17B10 | |
| SCHEMBL8048125 | 0.85 | CTSK (0.41) | F2RL3ALDH1A1L3MBTL1MAPTALOX5 | |
| SCHEMBL8033655 | 0.85 | EIF4E (0.34) | F2RL3ALDH1A1L3MBTL1MAPTALOX5 | |
| SCHEMBL8050843 | 0.84 | CTSS (0.38) | F2RL3ALDH1A1L3MBTL1MAPTALOX5 | |
| SCHEMBL8044775 | 0.83 | EIF4E (0.33) | F2RL3ALDH1A1L3MBTL1MAPTALOX5 | |
| SCHEMBL8033608 | 0.81 | EIF4E (0.40) | ALDH1A1L3MBTL1RORBEIF4EPPARD | |
| SCHEMBL8042665 | 0.81 | MAPT (0.41) | F2RL3POLBMAPTLMNAPKM | |
| SCHEMBL8048108 | 0.80 | KMT2A (0.40) | ALDH1A1L3MBTL1POLBMAPTPKM | |
| SCHEMBL8046645 | 0.80 | ALDH1A1 (0.39) | ALDH1A1L3MBTL1LMNAALOX5RORB | |
| SCHEMBL8043455 | 0.80 | LTA4H (0.42) | ALDH1A1ALOX5EIF4ELTA4HRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |