Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 5/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8050210 | 0.73 | HTR1A (0.48) | SMN1; SMN2RAB9ANPC1ALDH1A1LMNA | |
| SCHEMBL8043463 | 0.71 | FBP1 (0.47) | SMN1; SMN2NOS1ALDH1A1 | |
| SCHEMBL8043845 | 0.71 | HSD17B10 (0.45) | SMN1; SMN2RAB9ANPC1ALDH1A1LMNA | |
| SCHEMBL8050293 | 0.71 | RAB9A (0.42) | SMN1; SMN2RAB9ANPC1ALDH1A1LMNA | |
| SCHEMBL8713793 | 0.70 | NPC1 (0.31) | SMN1; SMN2RAB9ANPC1NPSR1 | |
| SCHEMBL8710549 | 0.69 | NPC1 (0.33) | SMN1; SMN2RAB9ANPC1ALDH1A1NPSR1 | |
| SCHEMBL5804686 | 0.68 | SMN1; SMN2 (0.48) | SMN1; SMN2NOS1RAB9ANPC1ALDH1A1 | |
| SCHEMBL8048057 | 0.67 | RAB9A (0.39) | SMN1; SMN2NOS1RAB9AALDH1A1LMNA | |
| SCHEMBL903172 | 0.66 | — | — | |
| SCHEMBL15948524 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |