Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8041797 | 0.85 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1HPGDPOLBMAPK1 | |
| SCHEMBL8042769 | 0.83 | AKR1B1 (0.40) | RECQLMAPTAKR1B1NPC1MEN1 | |
| SCHEMBL8052354 | 0.82 | L3MBTL1 (0.46) | ALDH1A1HPGDMAPK1HSD17B10TSHR | |
| SCHEMBL8041981 | 0.82 | FBP1 (0.50) | SMN1; SMN2ALDH1A1HPGDPOLBMAPK1 | |
| SCHEMBL8042780 | 0.82 | KDM4E (0.43) | SMN1; SMN2ALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL8047843 | 0.82 | PDK1 (0.53) | SMN1; SMN2ALDH1A1MAPK1TSHRMAPT | |
| SCHEMBL8048727 | 0.81 | CYP1A2 (0.43) | SMN1; SMN2ALDH1A1HPGDPOLBMAPK1 | |
| SCHEMBL8045191 | 0.80 | FBP1 (0.48) | SMN1; SMN2ALDH1A1HPGDMAPK1HSD17B10 | |
| SCHEMBL8047618 | 0.79 | RAB9A (0.46) | SMN1; SMN2ALDH1A1HPGDPOLBMAPK1 | |
| SCHEMBL8046519 | 0.78 | HSP90AA1 (0.49) | SMN1; SMN2ALDH1A1HPGDMAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |