Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | HPGD | P15428 | 5/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | TSHR | P16473 | 5/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8046519 | 0.93 | HSP90AA1 (0.49) | FBP1ALDH1A1MAPTHPGDMAPK1 | |
| SCHEMBL8041981 | 0.90 | FBP1 (0.50) | FBP1ALDH1A1MAPTHPGDMAPK1 | |
| SCHEMBL8048727 | 0.85 | CYP1A2 (0.43) | FBP1ALDH1A1MAPTHPGDMAPK1 | |
| SCHEMBL8042675 | 0.82 | ALDH1A1 (0.51) | FBP1ALDH1A1MAPTHPGDMAPK1 | |
| SCHEMBL8041887 | 0.82 | HSP90AA1 (0.47) | ALDH1A1MAPTHPGDMAPK1LMNA | |
| SCHEMBL8052354 | 0.82 | L3MBTL1 (0.46) | FBP1ALDH1A1MAPTHPGDMAPK1 | |
| SCHEMBL8043224 | 0.81 | SMN1; SMN2 (0.44) | ALDH1A1MAPTHPGDLMNASMN1; SMN2 | |
| SCHEMBL8047172 | 0.81 | SMN1; SMN2 (0.44) | ALDH1A1MAPTHPGDLMNAHSD17B10 | |
| SCHEMBL8046659 | 0.80 | PDK1 (0.54) | ALDH1A1MAPTMAPK1LMNATSHR | |
| SCHEMBL8043551 | 0.80 | SMN1; SMN2 (0.51) | FBP1ALDH1A1MAPTHPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |