Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8051238 | 0.83 | HSD17B10 (0.42) | SMN1; SMN2RAB9AALDH1A1HPGDLMNA | |
| SCHEMBL8032361 | 0.82 | ALDH1A1 (0.47) | SMN1; SMN2RAB9AALDH1A1LMNAKMT2A | |
| SCHEMBL8048335 | 0.80 | RAB9A (0.45) | SMN1; SMN2RAB9AALDH1A1HPGDLMNA | |
| SCHEMBL8044019 | 0.80 | KMT2A (0.40) | SMN1; SMN2RAB9AALDH1A1LMNAKMT2A | |
| SCHEMBL8047351 | 0.78 | KMT2A (0.47) | RAB9AALDH1A1HPGDLMNAKMT2A | |
| SCHEMBL8044036 | 0.77 | KMT2A (0.44) | SMN1; SMN2RAB9AALDH1A1HPGDLMNA | |
| SCHEMBL8042823 | 0.77 | ALDH1A1 (0.44) | SMN1; SMN2RAB9AALDH1A1HPGDLMNA | |
| SCHEMBL8046169 | 0.77 | KDM4C (0.39) | SMN1; SMN2RAB9AALDH1A1HPGDLMNA | |
| SCHEMBL8033559 | 0.76 | LMNA (0.47) | RAB9AALDH1A1LMNAKMT2ANPC1 | |
| SCHEMBL8048771 | 0.75 | MAPT (0.37) | ALDH1A1HPGDLMNAKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |