Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | EIF4E | P06730 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8052850 | 0.85 | KMT2A (0.43) | KDM4EALDH1A1KMT2AMEN1RAB9A | |
| SCHEMBL8051771 | 0.78 | ALOX5 (0.36) | KDM4EALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL8034012 | 0.78 | LTA4H (0.37) | MAPTEIF4EALOX5NPSR1 | |
| SCHEMBL8033982 | 0.78 | KDM4E (0.50) | KDM4EALDH1A1HSD17B10KMT2AMEN1 | |
| SCHEMBL8042665 | 0.77 | MAPT (0.41) | KMT2AMAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL8043455 | 0.77 | LTA4H (0.42) | KDM4EALDH1A1KMT2AMEN1RAB9A | |
| SCHEMBL8046557 | 0.77 | CTSS (0.35) | KDM4EALDH1A1HSD17B10KMT2AMEN1 | |
| SCHEMBL8033655 | 0.77 | EIF4E (0.34) | KDM4EALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL8043471 | 0.76 | KDM4E (0.41) | KDM4EALDH1A1EPHX2HSD17B10KMT2A | |
| SCHEMBL8048151 | 0.76 | F2RL3 (0.37) | ALDH1A1HSD17B10MAPTRAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |