Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 8/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.34 |
| ▸ | MEN1 | O00255 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8050838 | 0.87 | KDM4E (0.36) | PTGS2MAPTPOLBKDM4ELMNA | |
| SCHEMBL8043905 | 0.87 | KDM4E (0.37) | MAPTKDM4ELMNAKMT2AMEN1 | |
| SCHEMBL8043200 | 0.87 | ALDH1A1 (0.43) | MAPTPOLBKDM4ELMNAKMT2A | |
| SCHEMBL8047017 | 0.86 | HSP90AA1 (0.44) | PTGS2MAPTPOLBKDM4ELMNA | |
| SCHEMBL8043968 | 0.83 | MEN1 (0.45) | POLBKDM4ELMNAKMT2AMEN1 | |
| SCHEMBL8044654 | 0.83 | MAPT (0.44) | PTGS2MAPTPOLBKDM4ELMNA | |
| SCHEMBL8033936 | 0.83 | ALDH1A1 (0.42) | MAPTPOLBKDM4ELMNAKMT2A | |
| SCHEMBL8043931 | 0.83 | PTGS2 (0.43) | PTGS2PTGS1CYP2C9 | |
| SCHEMBL8037043 | 0.83 | SMN1; SMN2 (0.39) | MAPTKDM4ELMNAKMT2AMEN1 | |
| SCHEMBL8048028 | 0.82 | KMT2A (0.44) | PTGS2MAPTPOLBKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |