Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | EIF4E | P06730 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 2/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8046511 | 0.86 | HTT (0.45) | MAPTHTTPAX8PIP4K2CALOX5 | |
| SCHEMBL8048290 | 0.84 | MAPT (0.35) | MAPTHTTPAX8PIP4K2CALOX5 | |
| SCHEMBL8032734 | 0.83 | ALDH1A1 (0.37) | MAPTHTTPAX8PIP4K2CALOX5 | |
| SCHEMBL8044430 | 0.81 | CTSS (0.34) | MAPTHTTPAX8PIP4K2CALOX5 | |
| SCHEMBL8032494 | 0.81 | HTR1A (0.43) | MAPTHTTALDH1A1KDM4E | |
| SCHEMBL8043192 | 0.79 | ALDH1A1 (0.35) | MAPTHTTPAX8PIP4K2CALDH1A1 | |
| SCHEMBL8043200 | 0.79 | ALDH1A1 (0.43) | MAPTHTTALDH1A1L3MBTL1KDM4E | |
| SCHEMBL8050228 | 0.79 | RAB9A (0.41) | MAPTHTTPIP4K2CALDH1A1L3MBTL1 | |
| SCHEMBL8033766 | 0.78 | F2RL3 (0.36) | MAPTALOX5F2RL3EIF4EAR | |
| SCHEMBL8050838 | 0.78 | KDM4E (0.36) | MAPTHTTPAX8PIP4K2CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |