Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8033250 | 0.93 | HTT (0.41) | HSD17B10KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL8041836 | 0.90 | ALDH1A1 (0.42) | HSD17B10NPSR1KMT2AALDH1A1LMNA | |
| SCHEMBL8047435 | 0.86 | LMNA (0.33) | KMT2ALMNAHTT | |
| SCHEMBL8052603 | 0.85 | DCUN1D1 (0.37) | KMT2ALMNAHTT | |
| SCHEMBL8714264 | 0.85 | CYP2C19 (0.43) | HSD17B10KMT2AALDH1A1LMNAMEN1 | |
| SCHEMBL8046664 | 0.84 | CA12 (0.42) | HSD17B10KMT2AALDH1A1LMNAMEN1 | |
| SCHEMBL8044868 | 0.84 | ALDH1A1 (0.38) | HSD17B10NPSR1KMT2AALDH1A1LMNA | |
| SCHEMBL8050401 | 0.83 | KMT2A (0.36) | HSD17B10KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL8050069 | 0.81 | ALDH1A1 (0.45) | KMT2AALDH1A1LMNAMEN1RAB9A | |
| SCHEMBL8044080 | 0.81 | ALDH1A1 (0.40) | HSD17B10NPSR1KMT2AALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |