Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8033250 | 0.87 | HTT (0.41) | CYP2C19ALDH1A1LMNAUSP2HSD17B10 | |
| SCHEMBL8047435 | 0.85 | LMNA (0.33) | LMNAKMT2AHTT | |
| SCHEMBL8045938 | 0.85 | HSD17B10 (0.40) | ALDH1A1TP53LMNASMN1; SMN2HSD17B10 | |
| SCHEMBL8052603 | 0.84 | DCUN1D1 (0.37) | LMNAKMT2AHTT | |
| SCHEMBL8041836 | 0.82 | ALDH1A1 (0.42) | CYP2C19ALDH1A1TP53LMNASMN1; SMN2 | |
| SCHEMBL8716288 | 0.81 | CYP2C19 (0.47) | CYP2C19CYP2C9ALDH1A1TP53LMNA | |
| SCHEMBL8044040 | 0.81 | MAPK8 (0.52) | CYP2C19CYP2C9ALDH1A1TP53LMNA | |
| SCHEMBL8046664 | 0.80 | CA12 (0.42) | CYP2C19ALDH1A1TP53LMNASMN1; SMN2 | |
| SCHEMBL8044868 | 0.79 | ALDH1A1 (0.38) | ALDH1A1TP53LMNASMN1; SMN2HSD17B10 | |
| SCHEMBL8050401 | 0.78 | KMT2A (0.36) | ALDH1A1TP53LMNASMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |