Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 2/20 | 0.58 |
| ▸ | LTA4H | P09960 | 8/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.46 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1221676 | 0.85 | WDR5 (0.64) | WDR5PRSS1PRSS2PRSS3F10 | |
| Hydrochloric Acid SCHEMBL3764249 | 0.83 | WDR5 (0.62) | WDR5PRSS1PRSS2PRSS3F10 | |
| SCHEMBL8046153 | 0.79 | LTA4H (0.53) | LTA4HL3MBTL1LMNAMAPK1CASP3 | |
| SCHEMBL8046154 | 0.79 | L3MBTL1 (0.49) | LTA4HL3MBTL1LMNAMAPK1CASP3 | |
| SCHEMBL8046150 | 0.79 | LTA4H (0.53) | LTA4HL3MBTL1LMNAMAPK1CASP3 | |
| SCHEMBL5004504 | 0.78 | ALOX15 (0.70) | LTA4HL3MBTL1LMNAMAPK1CASP3 | |
| SCHEMBL13696728 | 0.77 | LTA4H (0.51) | LTA4HL3MBTL1LMNAMAPK1CASP3 | |
| SCHEMBL21360541 | 0.76 | FFAR1 (0.56) | WDR5PRSS1PRSS2PRSS3 | |
| Hydrochloric Acid SCHEMBL7317832 | 0.76 | F2 (0.79) | MRGPRX1PRSS1PRSS2PRSS3F10 | |
| SCHEMBL7141666 | 0.75 | GPR174 (0.56) | LTA4HL3MBTL1LMNAMAPK1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0971909-A1 | LTA 4? HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 2000-01-19 | — | — | EP | claimed |
| WO-1998040370-A1 | LTA4 HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-09-17 | — | — | WO | claimed |
| US-6110944-A | AN ANTIINFLAMMATORY AGENT TREATING INFLAMMATORY BOWEL DISEASE | G. D. SEARLE & CO. (US) | 2000-08-29 | — | — | US | disclosed |
| EP-0971909-A1 | LTA 4? HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998040370-A1 | LTA4 HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-09-17 | — | — | WO | disclosed |