Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | EIF4E | P06730 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | ICMT | O60725 | 1/20 | 0.34 |
| ▸ | RORB | Q92753 | 2/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8033608 | 0.90 | EIF4E (0.40) | ALDH1A1L3MBTL1EIF4EMEN1RORB | |
| SCHEMBL8033655 | 0.85 | EIF4E (0.34) | ALDH1A1L3MBTL1SCN9AEIF4EMEN1 | |
| SCHEMBL8048108 | 0.85 | KMT2A (0.40) | ALDH1A1L3MBTL1EIF4EMEN1SMN1; SMN2 | |
| SCHEMBL8050203 | 0.84 | RXRA (0.41) | ALDH1A1L3MBTL1LMNAEIF4EMEN1 | |
| SCHEMBL8044775 | 0.83 | EIF4E (0.33) | ALDH1A1L3MBTL1EIF4EMEN1KDM4E | |
| SCHEMBL8046557 | 0.83 | CTSS (0.35) | ALDH1A1L3MBTL1EIF4EMEN1KDM4E | |
| SCHEMBL8048125 | 0.81 | CTSK (0.41) | ALDH1A1L3MBTL1RAB9AEIF4EKMT2A | |
| SCHEMBL8043684 | 0.81 | RAB9A (0.48) | ALDH1A1L3MBTL1LMNARAB9ASCN9A | |
| SCHEMBL8048151 | 0.80 | F2RL3 (0.37) | ALDH1A1L3MBTL1LMNARAB9AEIF4E | |
| SCHEMBL8050843 | 0.80 | CTSS (0.38) | ALDH1A1L3MBTL1EIF4EALOX5HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |