Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8048207 | 0.91 | SIGMAR1 (0.45) | NPC1RAB9ASIGMAR1TMEM97OPRK1 | |
| SCHEMBL8053341 | 0.85 | RAB9A (0.47) | NPC1RAB9ASIGMAR1OPRK1LMNA | |
| SCHEMBL8053417 | 0.85 | SIGMAR1 (0.47) | NPC1RAB9ASIGMAR1TMEM97OPRM1 | |
| SCHEMBL8036049 | 0.84 | TMEM97 (0.52) | NPC1RAB9ASIGMAR1TMEM97OPRK1 | |
| SCHEMBL8787114 | 0.81 | ALDH1A1 (0.41) | NPC1SIGMAR1TMEM97ALDH1A1LMNA | |
| SCHEMBL8053395 | 0.79 | SIGMAR1 (0.58) | NPC1RAB9ASIGMAR1TMEM97OPRM1 | |
| SCHEMBL8045655 | 0.79 | HPGD (0.48) | NPC1RAB9AOPRK1ALDH1A1HPGD | |
| SCHEMBL8046983 | 0.78 | NPC1 (0.40) | NPC1RAB9ASIGMAR1TMEM97OPRK1 | |
| SCHEMBL8035576 | 0.77 | HPGD (0.47) | NPC1RAB9AOPRK1HPGDHSD17B10 | |
| SCHEMBL8787321 | 0.76 | APP (0.43) | SIGMAR1TMEM97OPRK1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0679649-B1 | 2,3-Dihydrobenzofuran Derivatives | ASAHI CHEMICAL IND (JP) | 2000-04-26 | — | — | EP | disclosed |
| EP-0679649-A1 | 2,3-DIHYDROBENZOFURAN DERIVATIVE | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1995-11-02 | — | — | EP | disclosed |