Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | MEN1 | O00255 | 7/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.40 |
| ▸ | HPGD | P15428 | 7/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.40 |
| ▸ | RELA | Q04206 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | MITF | O75030 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | ILK | Q13418 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8046550 | 0.88 | ALDH1A1 (0.40) | ALDH1A1MEN1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL8052167 | 0.87 | ALDH1A1 (0.41) | ALDH1A1MEN1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL8044245 | 0.85 | MEN1 (0.46) | ALDH1A1MEN1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL8033820 | 0.84 | ALDH1A1 (0.49) | ALDH1A1MEN1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL8042685 | 0.84 | NFKB1 (0.42) | ALDH1A1MEN1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL8044411 | 0.83 | KMT2A (0.55) | ALDH1A1MEN1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL8044910 | 0.82 | NPC1 (0.43) | ALDH1A1MEN1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL8043375 | 0.82 | SMN1; SMN2 (0.45) | ALDH1A1MEN1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL8051869 | 0.81 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL8050208 | 0.81 | PDK1 (0.52) | ALDH1A1MEN1KMT2ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |