Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8041886 | 0.91 | SMN1; SMN2 (0.45) | NPC1RAB9AL3MBTL1HTTMEN1 | |
| SCHEMBL8033936 | 0.89 | ALDH1A1 (0.42) | L3MBTL1HTTMEN1KMT2ACYP1A2 | |
| SCHEMBL8041897 | 0.84 | ALDH1A1 (0.47) | HTTMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL8045341 | 0.81 | ALDH1A1 (0.49) | L3MBTL1HTTKMT2ACYP1A2LMNA | |
| SCHEMBL8043200 | 0.81 | ALDH1A1 (0.43) | L3MBTL1HTTKMT2ALMNAMAPT | |
| SCHEMBL8044564 | 0.80 | CYP19A1 (0.48) | NPC1RAB9AL3MBTL1HTTMEN1 | |
| SCHEMBL8033588 | 0.78 | HSD17B10 (0.45) | NPC1RAB9AHTTMEN1KMT2A | |
| SCHEMBL8043675 | 0.77 | KIT (0.39) | L3MBTL1HTTCYP3A4CYP2C19KDM4E | |
| SCHEMBL8048340 | 0.76 | ALDH1A1 (0.45) | NPC1RAB9AHTTMEN1KMT2A | |
| SCHEMBL8048205 | 0.76 | ALDH1A1 (0.42) | NPC1RAB9AL3MBTL1HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |