Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HB | P07237 | 4/20 | 0.63 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.50 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.50 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | VNN1 | O95497 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | SNCA | P37840 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6748653 | 0.84 | SIRT1 (0.54) | P4HBHSD17B14CA1CA2GAA | |
| SCHEMBL29748711 | 0.84 | HSD17B1 (0.59) | P4HBHSD17B1HSD17B2HSD17B14ACHE | |
| SCHEMBL27661242 | 0.84 | HSD17B1 (0.59) | P4HBHSD17B1HSD17B2HSD17B14ACHE | |
| SCHEMBL3433075 | 0.80 | CA2 (0.67) | P4HBVNN1CA1CA2LMNA | |
| SCHEMBL3468841 | 0.79 | KDM4E (0.68) | P4HBHSD17B1HSD17B2ACHEVNN1 | |
| SCHEMBL9428615 | 0.79 | ACHE (0.66) | P4HBHSD17B1HSD17B2HSD17B14ACHE | |
| SCHEMBL8047746 | 0.78 | HTT (0.58) | ACHEVNN1GAASMN1; SMN2LMNA | |
| SCHEMBL7935350 | 0.78 | VNN1 (0.60) | VNN1CA1CA2SMN1; SMN2KDM4E | |
| SCHEMBL200168 | 0.78 | P4HB (0.51) | P4HBHSD17B14CA2CYP19A1ESR1 | |
| SCHEMBL29826346 | 0.78 | P4HB (0.51) | P4HBHSD17B14CA2CYP19A1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1087934-C | Use of phenalkylamines | HOFFMANN LA ROCHE (CH) | 2002-07-24 | — | — | CN | disclosed |
| EP-0636367-B1 | Use of phenylalkylamines for producing cholesterol lowering agents | HOFFMANN LA ROCHE (CH) | 2000-03-29 | — | — | EP | disclosed |
| US-5637771-A | Compound useful for lowering cholesterol | HOFFMANN-LA ROCHE INC. (US) | 1997-06-10 | — | — | US | disclosed |
| US-5574071-A | ADMINISTERING PHENYLALKYLAMINO KETONES | HOFFMANN-LA ROCHE INC. (US) | 1996-11-12 | — | — | US | disclosed |
| US-5495048-A | ANTICHOLESTEROL AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |
| CN-1103781-A | Use of phenalkylamines | HOFFMANN LA ROCHE (CH) | 1995-06-21 | — | — | CN | disclosed |
| EP-0636367-A1 | Use of phenylalkylamines for producing cholesterol lowering agents | F. HOFFMANN-LA ROCHE AG (CH) | 1995-02-01 | — | — | EP | disclosed |