Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 3/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4541277 | 0.79 | HSD11B1 (0.46) | ALDH1A1KMT2AMCOLN3FAAHHDAC3 | |
| SCHEMBL8051885 | 0.79 | BDKRB1 (0.53) | ALDH1A1KMT2AOPRM1OPRK1PSEN1 | |
| SCHEMBL14530359 | 0.78 | HSD11B1 (0.52) | FAAHHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8060153 | 0.78 | HDAC3 (0.59) | ALDH1A1FAAHHDAC3HDAC4HDAC1 | |
| SCHEMBL8069484 | 0.76 | PSEN1 (0.62) | ALDH1A1KMT2APSEN1PSEN2APH1B | |
| SCHEMBL4531367 | 0.76 | RAB9A (0.43) | ALDH1A1KMT2AMCOLN3OPRM1OPRK1 | |
| SCHEMBL4541290 | 0.75 | HSD11B1 (0.47) | ALDH1A1KMT2AFAAHHDAC3HDAC4 | |
| SCHEMBL4534767 | 0.74 | FAAH (0.41) | ALDH1A1KMT2AMCOLN3OPRM1OPRK1 | |
| SCHEMBL4531364 | 0.74 | HSD11B1 (0.44) | ALDH1A1KMT2AMCOLN3OPRM1OPRK1 | |
| SCHEMBL3727147 | 0.74 | MMP8 (0.58) | ALDH1A1FAAHHSD11B1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |