Sugi Predict

Sugi Predict / Compounds / SCHEMBL805340

SCHEMBL805340

SCHEMBL805340

COc1ccc(C(=O)/C=C/N(C)C)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 7/20 1.00
▸ ALDH1A1 P00352 5/20 1.00
▸ HPGD P15428 2/20 1.00
▸ RAB9A P51151 5/20 0.69
▸ POLB P06746 3/20 0.69
▸ NPC1 O15118 2/20 0.69
▸ HSP90AA1 P07900 1/20 0.69
▸ SMN1; SMN2 Q16637 1/20 0.69
▸ LMNA P02545 4/20 0.64
▸ CYP1A2 P05177 3/20 0.64
▸ CYP2C19 P33261 3/20 0.64
▸ RECQL P46063 2/20 0.64
▸ ALOX12 P18054 1/20 0.64
▸ F3 P13726 1/20 0.62
▸ HTT P42858 2/20 0.61
▸ GAA P10253 1/20 0.61
▸ MAOB P27338 3/20 0.59
▸ CYP3A4 P08684 1/20 0.58
▸ KMT2A Q03164 4/20 0.57
▸ MEN1 O00255 3/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL782731 1.00 MAPT (1.00) MAPTALDH1A1HPGDRAB9APOLB
SCHEMBL29419236 1.00 MAPT (1.00) MAPTALDH1A1HPGDRAB9APOLB
SCHEMBL23251385 0.87 MAPT (0.81) MAPTALDH1A1HPGDRAB9APOLB
SCHEMBL31276382 0.85 MAPT (0.74) MAPTALDH1A1HPGDRAB9APOLB
SCHEMBL7000261 0.85 F3 (0.75) MAPTALDH1A1HPGDRAB9ANPC1
SCHEMBL7000262 0.85 F3 (0.75) MAPTALDH1A1HPGDRAB9ANPC1
SCHEMBL950110 0.82 MAPT (0.70) MAPTALDH1A1HPGDRAB9APOLB
SCHEMBL950108 0.82 MAPT (0.70) MAPTALDH1A1HPGDRAB9APOLB
SCHEMBL28865784 0.81 ALDH1A1 (1.00) MAPTALDH1A1HPGDRAB9APOLB
SCHEMBL31276086 0.81 MAPT (0.69) MAPTALDH1A1HPGDRAB9APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 100 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119019332-A 1, 5-Disubstituted-4-bromopyrazole compound and preparation method and application thereof 赣南师范大学 2024-11-26 — — CN claimed
CN-116396145-A Preparation method of 9-phenanthrene phenol compound 西北工业大学 2023-07-07 — — CN claimed
US-20250288589-A1 PYRIDOPYRIMIDINES AND METHODS OF THEIR USE Kineta, Inc. 2025-09-18 — — US disclosed
CN-119019332-A 1, 5-Disubstituted-4-bromopyrazole compound and preparation method and application thereof 赣南师范大学 2024-11-26 — — CN disclosed
EP-4444289-A1 PYRIDOPYRIMIDINES AND METHODS OF THEIR USE Kineta, Inc. (US) 2024-10-16 — — EP disclosed
CN-115215796-B Synthesis method of 3-acyl quinoline compound 江南大学 2023-10-27 — — CN disclosed
US-11773121-B2 Antiviral compounds VIROVAX LLC (US) 2023-10-03 — — US disclosed
US-20230303561-A1 PYRIMIDINONE DERIVATIVE, PREPARATION METHOD THEREOF AND USE THEREOF IN RESISTING MYCOBACTERIUM TUBERCULOSIS INFECTION INSTITUTE OF MEDICINAL BIOTECHNOLOGY, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) 2023-09-28 — — US disclosed
US-20230303561-A1 PYRIMIDINONE DERIVATIVE, PREPARATION METHOD THEREOF AND USE THEREOF IN RESISTING MYCOBACTERIUM TUBERCULOSIS INFECTION INSTITUTE OF MEDICINAL BIOTECHNOLOGY, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) 2023-09-28 — — US disclosed
CN-116396145-A Preparation method of 9-phenanthrene phenol compound 西北工业大学 2023-07-07 — — CN disclosed
WO-2023107592-A1 PYRIDOPYRIMIDINES AND METHODS OF THEIR USE Kineta, Inc. (US) 2023-06-15 — — WO disclosed
WO-2003072572-A1 BETA3-ADRENERGIC RECEPTOR AGONISTS PFIZER PRODUCTS INC. (US) 2003-09-04 — — WO disclosed
EP-0862560-B1 SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS CELLTECH THERAPEUTICS LTD (GB) 2003-04-02 — — EP disclosed
US-6235746-B1 AUTOIMMUNE DISEASES; ANTIPROLIFERATIVE AGENT CELLTECH THERAPEUTICS, LIMITED (GB) 2001-05-22 — — US disclosed
US-5958935-A Substituted 2-anilinopyrimidines useful as protein kinase inhibitors CELLTECH THERAPEUTICS LIMITED (GB) 1999-09-28 — — US disclosed
EP-0862560-A1 SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS CELLTECH THERAPEUTICS LIMITED (GB) 1998-09-09 — — EP disclosed
WO-1997019065-A1 SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS CELLTECH THERAPEUTICS LIMITED (GB) 1997-05-29 — — WO disclosed
US-4904658-A Substituted-6H,8H-pyrimido-[1,2,3-cd]purine-8,10-(9H)-diones and substituted-6H,10H-pyrimido[1,2-cd]purin-10-ones AMERICAN CYANAMID COMPANY (US) 1990-02-27 — — US disclosed
US-4888345-A HYPOTENSIVE AND ANXIOLYTIC AGENTS; CHEMICAL INTERMEDIATES AMERICAN CYANAMID COMPANY (US) 1989-12-19 — — US disclosed
US-4209621-A TRANQUILIZERS AMERICAN CYANAMID COMPANY (US) 1980-06-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230303561-A1 PYRIMIDINONE DERIVATIVE, PREPARATION METHOD THEREOF AND USE THEREOF IN RESISTING MYCOBACTERIUM TUBERCULOSIS INFECTION DHPS, DHFR, QDPR MAPT 3364/4885ALDH1A1 234/4885HPGD 192/4885
US-20250288589-A1 PYRIDOPYRIMIDINES AND METHODS OF THEIR USE PNPO, DPYD, PYGB MAPT 227/4885ALDH1A1 945/4885HPGD 314/4885
US-11773121-B2 Antiviral compounds ZC3HAV1, SARS1, ZC3HAV1L MAPT 203/4885ALDH1A1 915/4885HPGD 2274/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.