Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 7/20 | 0.33 |
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.32 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.32 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.32 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.32 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.33 |
| ▸ | GCGR | P47871 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 4/20 | 0.32 |
| ▸ | DRD4 | P21917 | 4/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | HTR7 | P34969 | 2/20 | 0.32 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8053531 | 1.00 | MDM2 (0.35) | MDM2MAPK14NPC1RAB9ADRD2 | |
| SCHEMBL8051800 | 0.95 | NPC1 (0.37) | MAPK14NPC1RAB9ADRD2KCNA3 | |
| SCHEMBL8050437 | 0.78 | SLC6A3 (0.33) | MAPK14GCGRMEN1KMT2A | |
| Fumaric Acid SCHEMBL8053529 | 0.78 | MDM2 (0.36) | MDM2NPC1RAB9A | |
| Fumaric Acid SCHEMBL8053536 | 0.78 | MDM2 (0.36) | MDM2NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL8040242 | 0.78 | SLC6A3 (0.32) | MAPK14GCGRMEN1KMT2A | |
| SCHEMBL8054066 | 0.77 | DRD2 (0.37) | MAPK14NPC1RAB9ADRD2KCNA3 | |
| Hydrochloric Acid SCHEMBL8056508 | 0.76 | DRD2 (0.37) | MAPK14NPC1RAB9ADRD2KCNA3 | |
| SCHEMBL8039432 | 0.74 | SLC6A2 (0.37) | MAPK14GCGRALDH1A1HTTNPSR1 | |
| Hydrochloric Acid SCHEMBL9425165 | 0.73 | SLC6A2 (0.37) | MAPK14GCGRALDH1A1HTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6022880-A | Substituted pyridylamino indoles | HOECHST MARION ROUSSEL, INC. (US) | 2000-02-08 | — | — | US | disclosed |
| US-5328920-A | Alleviating memory dysfunctions | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-07-12 | — | — | US | disclosed |