SCHEMBL8053716

SCHEMBL8053716

CCC/C(=N/CC)c1nc(C(CCCN2CCN(C)CC2)CC2CC2)[nH]c(=O)c1C

nearest known ligand 0.32

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
EED O75530 1/20 0.32
RBBP4 Q09028 1/20 0.32
SUZ12 Q15022 1/20 0.32
EZH2 Q15910 1/20 0.32
AEBP2 Q6ZN18 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8043288 0.68 RAB9A (0.35)
SCHEMBL8042668 0.61 SLC2A1 (0.32)
SCHEMBL15187056 0.52 USP2 (0.47)
SCHEMBL15187055 0.52 USP2 (0.47)
SCHEMBL20143830 0.50 PAOX (0.47)
SCHEMBL21981137 0.50 PAOX (0.39)
SCHEMBL12289113 0.50 USP2 (0.39)
SCHEMBL15187050 0.50 LMNA (0.44)
SCHEMBL15187304 0.50 LMNA (0.44)
SCHEMBL240855 0.49 GNAI3 (0.52)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009071707-A1 NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES GALAPAGOS NV (BE) 2009-06-11 WO disclosed