Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | PDE9A | O76083 | 1/20 | 0.31 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8034133 | 0.69 | KDM4E (0.36) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL8053716 | 0.68 | EED (0.32) | — | |
| SCHEMBL8031553 | 0.62 | KDM4E (0.34) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL4125201 | 0.61 | PDE5A (0.36) | KDM4EALDH1A1KMT2AMAPTCTDSP1 | |
| SCHEMBL4123024 | 0.60 | ALDH1A1 (0.36) | KDM4EALDH1A1MAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL8043292 | 0.58 | PDE5A (0.45) | ALDH1A1MEN1KMT2APDE9A | |
| SCHEMBL24784205 | 0.55 | KMT2A (0.49) | RAB9ANPC1ALDH1A1MEN1KMT2A | |
| SCHEMBL8190981 | 0.54 | KMT2A (0.46) | RAB9ANPC1KDM4EALDH1A1MEN1 | |
| SCHEMBL23747134 | 0.52 | GLA (0.58) | RAB9AALDH1A1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL18772826 | 0.52 | LMNA (0.34) | KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071707-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |