Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.41 |
| ▸ | ITGAL | P20701 | 1/20 | 0.41 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CRHBP | P24387 | 2/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.36 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.35 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17424104 | 1.00 | KCNH2 (0.43) | KCNH2ITGB2ICAM1ITGALMAP3K14 | |
| SCHEMBL22143980 | 1.00 | KCNH2 (0.43) | KCNH2ITGB2ICAM1ITGALMAP3K14 | |
| SCHEMBL21929395 | 0.82 | KCNH2 (0.42) | KCNH2ITGB2ICAM1ITGALMAP3K14 | |
| SCHEMBL2153529 | 0.82 | KCNH2 (0.45) | KCNH2HTR1A | |
| SCHEMBL29960467 | 0.81 | ITGB2 (0.41) | KCNH2ITGB2ICAM1ITGALHTR2A | |
| SCHEMBL29961247 | 0.81 | ITGB2 (0.41) | KCNH2ITGB2ICAM1ITGALMAP3K14 | |
| SCHEMBL4223377 | 0.81 | ITGB2 (0.41) | KCNH2ITGB2ICAM1ITGALHTR2A | |
| SCHEMBL27835409 | 0.81 | ITGB2 (0.41) | KCNH2ITGB2ICAM1ITGALMAP3K14 | |
| SCHEMBL3585379 | 0.81 | ITGB2 (0.41) | KCNH2ITGB2ICAM1ITGALMAP3K14 | |
| SCHEMBL19141630 | 0.81 | ITGB2 (0.41) | KCNH2ITGB2ICAM1ITGALMAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11858931-B2 | Amino acid compounds with unbranched linkers and methods of use | PLIANT THERAPEUTICS, INC. (US) | 2024-01-02 | — | — | US | disclosed |
| US-20230295181-A1 | INHIBITOR OF APOPTOSIS (IAP) PROTEIN ANTAGONISTS | Sanford Burnham Prebys Medical Discovery Institute | 2023-09-21 | — | — | US | disclosed |
| US-20230295111-A1 | IKAROS ZINC FINGER FAMILY DEGRADERS AND USES THEREOF | GILEAD SCIENCES, INC. | 2023-09-21 | — | — | US | disclosed |
| US-11753397-B2 | Cereblon binders for the degradation of ikaros | C4 THERAPEUTICS, INC. (US) | 2023-09-12 | — | — | US | disclosed |
| US-20230013692-A1 | ANTIMALARIAL AGENTS | MERCK SHARP & DOHME LLC (US) | 2023-01-19 | — | — | US | disclosed |
| US-20230009608-A1 | GRK2 INHIBITORS AND USES THEREOF | SONATA THERAPEUTICS, INC. | 2023-01-12 | — | — | US | disclosed |
| US-20220331321-A1 | ANTIMALARIAL AGENTS | MERCK SHARP & DOHME CORP. (US) | 2022-10-20 | — | — | US | disclosed |
| US-20210009559-A1 | CEREBLON BINDERS FOR THE DEGRADATION OF IKAROS | C4 THERAPEUTICS, INC. (US) | 2021-01-14 | — | — | US | disclosed |
| US-10544188-B2 | Inhibitor of apoptosis protein (IAP) antagonists | Sanford Burnham Prebys Medical Discovery Institute (US) | 2020-01-28 | — | — | US | disclosed |
| US-10300074-B2 | Use of inhibitor of apoptosis protein (IAP) antagonists in HIV therapy | Sanford Burnham Prebys Medical Discovery Institute (US) | 2019-05-28 | — | — | US | disclosed |
| US-8835440-B2 | Cyclic pyrimidin-4-carboxamides as CCR2 receptor antagonists for treatment of inflammation, asthma and COPD | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-09-16 | — | — | US | disclosed |
| US-20140235661-A1 | NEW CCR2 RECEPTOR ANTAGONISTS AND USES THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-08-21 | — | — | US | disclosed |
| US-8765949-B2 | CCR2 receptor antagonists and uses thereof | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-07-01 | — | — | US | disclosed |
| US-8252829-B2 | Aminopyrrolidinone derivatives and uses thereof | LINK MEDICINE CORPORATION (US) | 2012-08-28 | — | — | US | disclosed |
| EP-1848718-B1 | INHIBITORS OF E1 ACTIVATING ENZYMES | MILLENNIUM PHARM INC (US) | 2012-08-01 | — | — | EP | disclosed |
| US-20120071461-A1 | Substituted Benzamide Compounds | GRUENENTHAL GMBH (DE) | 2012-03-22 | — | — | US | disclosed |
| US-20120004252-A1 | NEW CCR2 RECEPTOR ANTAGONISTS AND USES THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-01-05 | — | — | US | disclosed |
| US-20110237590-A1 | PYRIDINE-3-CARBOXYAMIDE DERIVATIVE | KOWA COMPANY, LTD. (JP) | 2011-09-29 | — | — | US | disclosed |
| US-20110021590-A1 | AMINOPYRROLIDINONE DERIVATIVES AND USES THEREOF | LINK MEDICINE CORPORATION (US) | 2011-01-27 | — | — | US | disclosed |
| US-20080306136-A1 | Substituted Ureas and Carbamates | ELAN PHARMACEUTICALS, INC. | 2008-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (16 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120004252-A1 | NEW CCR2 RECEPTOR ANTAGONISTS AND USES THEREOF | CCR2, CCRL2, CCR1 | KCNH2 3611/4885ITGB2 531/4885ICAM1 431/4885 |
| US-20230009608-A1 | GRK2 INHIBITORS AND USES THEREOF | GRK2, GRK3, GRK1 | KCNH2 2429/4885ITGB2 1146/4885ICAM1 3764/4885 |
| US-11753397-B2 | Cereblon binders for the degradation of ikaros | CRBN, IKZF1, IKZF3 | KCNH2 3956/4885ITGB2 2541/4885ICAM1 2703/4885 |
| US-20140235661-A1 | NEW CCR2 RECEPTOR ANTAGONISTS AND USES THEREOF | CCR2, CCRL2, CCR1 | KCNH2 3611/4885ITGB2 531/4885ICAM1 431/4885 |
| US-20210009559-A1 | CEREBLON BINDERS FOR THE DEGRADATION OF IKAROS | CRBN, IKZF1, IKZF3 | KCNH2 4232/4885ITGB2 2475/4885ICAM1 2469/4885 |
| US-20080306136-A1 | Substituted Ureas and Carbamates | BACE1, BACE2, APP | KCNH2 3883/4885ITGB2 4764/4885ICAM1 3800/4885 |
| US-20230013692-A1 | ANTIMALARIAL AGENTS | CTSL, PRCP, PEPD | KCNH2 3824/4885ITGB2 3488/4885ICAM1 2232/4885 |
| US-10544188-B2 | Inhibitor of apoptosis protein (IAP) antagonists | API5, XIAP, BIRC5 | KCNH2 4495/4885ITGB2 4644/4885ICAM1 1217/4885 |
| US-10300074-B2 | Use of inhibitor of apoptosis protein (IAP) antagonists in HIV therapy | BIRC3, API5, XIAP | KCNH2 4790/4885ITGB2 4558/4885ICAM1 355/4885 |
| US-20230295181-A1 | INHIBITOR OF APOPTOSIS (IAP) PROTEIN ANTAGONISTS | API5, XIAP, BIRC5 | KCNH2 4533/4885ITGB2 4628/4885ICAM1 1613/4885 |
| US-20220331321-A1 | ANTIMALARIAL AGENTS | CTSL, SERPINA3, SERPINB1 | KCNH2 3818/4885ITGB2 2904/4885ICAM1 1770/4885 |
| US-20110021590-A1 | AMINOPYRROLIDINONE DERIVATIVES AND USES THEREOF | PRMT1, PRMT5, AGTR2 | KCNH2 1431/4885ITGB2 1744/4885ICAM1 2698/4885 |
| US-20230295111-A1 | IKAROS ZINC FINGER FAMILY DEGRADERS AND USES THEREOF | IKZF2, IKZF1, IKZF3 | KCNH2 3650/4885ITGB2 4446/4885ICAM1 2775/4885 |
| US-11858931-B2 | Amino acid compounds with unbranched linkers and methods of use | ITGA2B, ITGB6, ITGB1 | KCNH2 1325/4885ITGB2 9/4885ICAM1 119/4885 |
| US-20120071461-A1 | Substituted Benzamide Compounds | BDKRB1, BDKRB2, HRH2 | KCNH2 77/4885ITGB2 2443/4885ICAM1 1964/4885 |
| US-20110237590-A1 | PYRIDINE-3-CARBOXYAMIDE DERIVATIVE | JAK3, JAK1, UACA | KCNH2 3255/4885ITGB2 3322/4885ICAM1 1139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.