SCHEMBL8055374

SCHEMBL8055374

CC(C)c1cc(CNC(=O)c2ccc(C(=O)NCc3cc(C(C)C)cc(-n4nc5ccccc5n4)c3O)cc2)c(O)c(-n2nc3ccccc3n2)c1

nearest known ligand 0.44

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TTR P02766 1/20 0.44
PTGER4 P35408 1/20 0.41
SMN1; SMN2 Q16637 4/20 0.40
RAB9A P51151 4/20 0.40
KMT2A Q03164 2/20 0.40
TP53 P04637 1/20 0.40
MEN1 O00255 1/20 0.40
HDAC1 Q13547 5/20 0.39
LMNA P02545 1/20 0.39
NPC1 O15118 3/20 0.38
TRPV1 Q8NER1 1/20 0.38
ALDH1A1 P00352 2/20 0.38
HPGD P15428 1/20 0.38
POLB P06746 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8409160 0.95 TTR (0.40) TTRPTGER4SMN1; SMN2RAB9AKMT2A
SCHEMBL8043958 0.94 TTR (0.42) TTRPTGER4SMN1; SMN2RAB9AKMT2A
SCHEMBL8061708 0.90 TTR (0.41) TTRSMN1; SMN2RAB9AKMT2ATP53
SCHEMBL9408813 0.90 NPC1 (0.40) TTRPTGER4SMN1; SMN2RAB9AKMT2A
SCHEMBL8409285 0.89 MAP3K7 (0.39) TTRPTGER4SMN1; SMN2KMT2ATP53
SCHEMBL8407973 0.86 TTR (0.38) TTRSMN1; SMN2RAB9AKMT2AMEN1
SCHEMBL8043991 0.85 NPC1 (0.52) TTRSMN1; SMN2RAB9AKMT2ATP53
SCHEMBL8043973 0.84 HTT (0.40) TTRRAB9AKMT2AMEN1LMNA
SCHEMBL8056945 0.83 TTR (0.44) TTRSMN1; SMN2RAB9AKMT2AHDAC1
SCHEMBL8061576 0.82 LMNA (0.47) TTRSMN1; SMN2RAB9AKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0826511-B1 Heat sensitive recording material OJI PAPER CO (JP) 2000-05-24 EP disclosed
EP-0826511-A1 Heat sensitive recording material Oji Paper Co., Ltd. (JP) 1998-03-04 EP disclosed