Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | PKLR | P30613 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8045188 | 0.85 | EGFR (0.51) | HPGDALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL8060790 | 0.85 | ALDH1A1 (0.40) | HPGDALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL8068448 | 0.74 | GABRA1 (0.49) | HPGDALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL8071055 | 0.72 | ALDH1A1 (0.51) | HPGDALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL8060750 | 0.70 | LMNA (0.36) | HPGDALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL3748237 | 0.70 | EGFR (0.63) | HPGDALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL16419694 | 0.70 | GABRA1 (0.55) | HPGDALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL10058712 | 0.70 | EGFR (0.63) | HPGDALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL8059705 | 0.69 | CFTR (0.53) | HPGDALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL8608047 | 0.69 | PTGS2 (0.52) | HPGDALDH1A1MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6028069-A | Heterocyclyl-condensed benzoylguanidines, their production and use as inhibitors of the cellular Na+/H+-antiporter | MERCK PATENT GESELLSCHAFT MIT BERSCHRANKER HAFTUNG (DE) | 2000-02-22 | — | — | US | disclosed |