Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 15/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 15/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | PHGDH | O43175 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9540217 | 0.83 | P2RX7 (0.40) | P2RX7NR1H2NR1H3CHRNB2CHRNB4 | |
| SCHEMBL10927522 | 0.77 | P2RX7 (0.37) | P2RX7NR1H2NR1H3 | |
| SCHEMBL11860669 | 0.73 | CHRNB2 (0.47) | CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4 | |
| SCHEMBL27820682 | 0.69 | CHRNB2 (0.40) | P2RX7CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL9199829 | 0.69 | SIGMAR1 (0.40) | P2RX7CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL25533005 | 0.68 | P2RX7 (0.54) | P2RX7NR1H2NR1H3CHRNB2CHRNB4 | |
| SCHEMBL11938944 | 0.67 | MAPK1 (0.42) | P2RX7 | |
| SCHEMBL11932483 | 0.65 | HSP90AA1 (0.41) | P2RX7CHRNB2CHRNB4CHRNA3CHRNA7 | |
| Hydrochloric Acid SCHEMBL3672966 | 0.65 | SIGMAR1 (0.49) | — | |
| SCHEMBL27979543 | 0.63 | DRD2 (0.42) | CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998923-A1 | Use of 5-HT7 receptor agonists for the treatment or prophylaxis of ischemias | BASF AKTIENGESELLSCHAFT (DE) | 2000-05-10 | — | — | EP | disclosed |