Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4542922 | 0.85 | RAB9A (0.49) | RAB9ANPC1PAX8HCRTR1HCRTR2 | |
| SCHEMBL4537168 | 0.82 | RAB9A (0.47) | RAB9ANPC1PAX8LMNATSHR | |
| SCHEMBL8064682 | 0.81 | RAB9A (0.42) | RAB9ANPC1PAX8 | |
| SCHEMBL8062191 | 0.81 | RAB9A (0.49) | RAB9APAX8 | |
| SCHEMBL8068365 | 0.79 | RAB9A (0.42) | RAB9ANPC1PAX8LMNATSHR | |
| SCHEMBL8066489 | 0.77 | RAB9A (0.43) | RAB9ANPC1PAX8HCRTR1HCRTR2 | |
| SCHEMBL4542926 | 0.77 | RAB9A (0.54) | RAB9ANPC1PAX8HCRTR1HCRTR2 | |
| SCHEMBL4538117 | 0.75 | FKBP1A (0.48) | RAB9ANPC1PAX8LMNAALDH1A1 | |
| SCHEMBL8060003 | 0.75 | RAB9A (0.41) | RAB9ANPC1PAX8LMNAALDH1A1 | |
| SCHEMBL4536862 | 0.74 | ALDH1A1 (0.52) | RAB9ANPC1PAX8ALDH1A1HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |