Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | CTSA | P10619 | 3/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
| ▸ | FNTB | P49356 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8053509 | 0.84 | GRM2 (0.46) | PDE4BALDH1A1PKMHSP90AA1PDE4D | |
| SCHEMBL3809328 | 0.82 | ALDH1A1 (0.52) | PDE4BALDH1A1PKMPDE4DSMN1; SMN2 | |
| SCHEMBL8064712 | 0.79 | PDE4B (0.45) | PDE4BPDE4DCTSAFNTAFNTB | |
| SCHEMBL7904659 | 0.76 | CYP19A1 (0.47) | PDE4B | |
| SCHEMBL8064800 | 0.75 | HTT (0.52) | PDE4BALDH1A1PDE4D | |
| SCHEMBL8067030 | 0.74 | PDE4D (0.49) | PDE4BALDH1A1PDE4DFFAR1SMN1; SMN2 | |
| SCHEMBL8014205 | 0.74 | PDE4B (0.46) | PDE4BALDH1A1PDE4DCTSAFFAR1 | |
| SCHEMBL8066867 | 0.74 | PDE4B (0.46) | PDE4BALDH1A1PDE4DCTSAFFAR1 | |
| SCHEMBL8068535 | 0.74 | HDAC7 (0.49) | PDE4BALDH1A1PDE4DGRM2 | |
| SCHEMBL8066070 | 0.74 | HTT (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |