SCHEMBL8065980

SCHEMBL8065980

CC(=O)c1cc2c(cc1C=O)C(C)(C)CCC2(C)C

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RXRA P19793 19/20 0.43
RARB P10826 12/20 0.43
RARG P13631 11/20 0.43
RXRB P28702 8/20 0.43
RARA P10276 7/20 0.43
RXRG P48443 7/20 0.43
MEN1 O00255 1/20 0.40
CYP26A1 O43174 1/20 0.40
ABCB11 O95342 1/20 0.40
ESR1 P03372 1/20 0.40
PGR P06401 1/20 0.40
HTR1A P08908 1/20 0.40
ADRA2A P08913 1/20 0.40
ADORA3 P0DMS8 1/20 0.40
CHRM1 P11229 1/20 0.40
DRD1 P21728 1/20 0.40
TBXA2R P21731 1/20 0.40
SLC6A2 P23975 1/20 0.40
ADRA1A P35348 1/20 0.40
OPRM1 P35372 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30368657 1.00 RXRA (0.43) RXRARARBRARGRXRBRARA
SCHEMBL12418596 0.83 RXRA (0.50) RXRARARBRARGRXRBRARA
SCHEMBL11122818 0.81 RARB (0.41) RXRARARBRARGRXRBRARA
SCHEMBL30232111 0.81 RARG (0.41) RXRARARBRARGRXRBRARA
SCHEMBL8056473 0.81 RARG (0.41) RXRARARBRARGRXRBRARA
SCHEMBL8807547 0.77 RXRA (0.44) RXRARARBRARGRXRBRARA
SCHEMBL3298635 0.77 RXRA (0.61) RXRARARBRARGRXRBRARA
SCHEMBL726366 0.77 RXRA (0.59) RXRARARBRARGRXRBRARA
SCHEMBL29260311 0.75 POLA1 (0.34)
SCHEMBL9859988 0.75 RXRA (0.60) RXRARARBRARGRXRBRARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10336966-B2 Fragrance compositions and uses thereof THE PROCTER & GAMBLE COMPANY (US) 2019-07-02 US claimed
US-6147049-A FRAGRANCE COMPOSITION GIVAUDAN ROURE (INTERNATIONAL) SA (CH) 2000-11-14 US claimed
EP-1010686-A1 New Tetrahydronaphthalenes Givaudan Roure (International) S.A. (CH) 2000-06-21 EP claimed
EP-1010685-A1 New tetrahydronaphthalenes Givaudan Roure (International) S.A. (CH) 2000-06-21 EP claimed
US-12527733-B2 Fragrance compositions ELC MANAGEMENT LLC (US) 2026-01-20 US disclosed
EP-3103523-B1 ABSORBENT ARTICLE COMPRISING FRAGRANCE COMPOSITION PROCTER & GAMBLE (US) 2025-10-29 EP disclosed
EP-4384137-A1 FRAGRANCE COMPOSITIONS ELC Management LLC (US) 2024-06-19 EP disclosed
US-20230048533-A1 FRAGRANCE COMPOSITIONS ELC MANAGEMENT LLC 2023-02-16 US disclosed
WO-2023018673-A1 FRAGRANCE COMPOSITIONS ELC MANAGEMENT LLC (US) 2023-02-16 WO disclosed
US-20210393506-A1 FRAGRANCE BLENDS AND METHODS FOR PREPARATION THEREOF JPMORGAN CHASE BANK, N.A. 2021-12-23 US disclosed
EP-3103431-A1 FRAGRANCE COMPOSITIONS AND USES THEREOF The Procter and Gamble Company (US) 2016-12-14 EP disclosed
EP-3103523-A1 ABSORBENT ARTICLE COMPRISING FRAGRANCE COMPOSITION The Procter and Gamble Company (US) 2016-12-14 EP disclosed
US-6147049-A FRAGRANCE COMPOSITION GIVAUDAN ROURE (INTERNATIONAL) SA (CH) 2000-11-14 US disclosed
JP-2000219651-A NEW TETRAHYDRONAPHTHALENE GIVAUDAN ROURE INTERNATL SA 2000-08-08 JP disclosed
EP-1010686-A1 New Tetrahydronaphthalenes Givaudan Roure (International) S.A. (CH) 2000-06-21 EP disclosed
EP-1010685-A1 New tetrahydronaphthalenes Givaudan Roure (International) S.A. (CH) 2000-06-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10336966-B2 Fragrance compositions and uses thereof CUTA, DPM1, PLIN5 RXRA 1429/4885RARB 2984/4885RARG 1890/4885
US-12527733-B2 Fragrance compositions CUTA, IL36G, TAS2R40 RXRA 2643/4885RARB 1335/4885RARG 465/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.