Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MEP1B | Q16820 | 2/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8068934 | 0.80 | SIGMAR1 (0.51) | MAPTGAAKMT2APOLBCCR2 | |
| SCHEMBL8068849 | 0.78 | ALDH1A1 (0.54) | TSHRALDH1A1MAPTKMT2AGFER | |
| SCHEMBL8059681 | 0.77 | TTR (0.45) | NPSR1MAPTGAAGFERPOLB | |
| SCHEMBL8073502 | 0.76 | TTR (0.51) | ALDH1A1NPSR1MAPTGAAPOLB | |
| SCHEMBL8073771 | 0.75 | KMT2A (0.58) | TSHRALDH1A1NPSR1KMT2APOLB | |
| Piperidine SCHEMBL8073727 | 0.74 | PKM (0.48) | TSHRALDH1A1NPSR1POLBPKM | |
| SCHEMBL8447165 | 0.74 | NPSR1 (0.45) | ALDH1A1NPSR1GFERPOLBPKM | |
| SCHEMBL8059364 | 0.74 | PKM (0.55) | ALDH1A1POLBPKMTDP1L3MBTL1 | |
| SCHEMBL8070556 | 0.74 | MAPT (0.47) | TSHRMAPTKMT2APOLBPKM | |
| SCHEMBL8059678 | 0.74 | NPSR1 (0.44) | ALDH1A1NPSR1KMT2APOLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057322-A | USEFUL IN TREATMENT OF CARDIOVASCULAR DISEASES | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-05-02 | — | — | US | disclosed |