Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | RXRA | P19793 | 3/20 | 0.41 |
| ▸ | RXRB | P28702 | 3/20 | 0.41 |
| ▸ | RXRG | P48443 | 3/20 | 0.41 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.41 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 6/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8068641 | 0.84 | SIRT1 (0.41) | THRATHRBLPAR1LPAR5MRGPRX4 | |
| Hydrochloric Acid SCHEMBL8073699 | 0.81 | PKM (0.43) | THRATHRBPOLBPKMBCHE | |
| SCHEMBL8068627 | 0.72 | LPAR1 (0.48) | THRATHRBLPAR1LPAR5MRGPRX4 | |
| SCHEMBL8068951 | 0.72 | LPAR1 (0.46) | THRATHRBRXRARXRBRXRG | |
| SCHEMBL8059726 | 0.69 | THRA (0.47) | THRATHRBRXRARXRBRXRG | |
| SCHEMBL8074970 | 0.68 | SLC6A2 (0.45) | THRATHRBLPAR1LPAR5SIRT1 | |
| Hydrochloric Acid SCHEMBL8070331 | 0.67 | SLC6A2 (0.44) | THRATHRBLPAR1LPAR5SIRT1 | |
| SCHEMBL30835355 | 0.67 | RXRA (0.46) | THRATHRBRXRARXRBRXRG | |
| SCHEMBL615379 | 0.66 | CA12 (0.62) | RXRARXRBRXRGMRGPRX4PKM | |
| SCHEMBL3529077 | 0.66 | HCAR3 (0.46) | THRATHRBRXRARXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057322-A | USEFUL IN TREATMENT OF CARDIOVASCULAR DISEASES | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-05-02 | — | — | US | disclosed |