SCHEMBL8069949

SCHEMBL8069949

CC(C)(C)OC(=O)N1C(=O)C2=C(c3cccc(Cl)c3)N(C(=O)OC(C)(C)C)C(=O)C2=C1c1cccc(Cl)c1

nearest known ligand 0.43

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
XPO1 O14980 1/20 0.43
STS P08842 1/20 0.39
USP30 Q70CQ3 3/20 0.39
HSP90AA1 P07900 2/20 0.39
HSP90AB1 P08238 2/20 0.39
BCHE P06276 1/20 0.39
UCHL1 P09936 1/20 0.37
CNR2 P34972 2/20 0.36
GRM5 P41594 1/20 0.36
PGR P06401 1/20 0.35
SLC6A3 Q01959 3/20 0.35
CTSL P07711 1/20 0.35
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
SLC6A2 P23975 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7754292 0.86 CNR1 (0.39) BCHEMEN1KMT2A
SCHEMBL8053167 0.85 GPR119 (0.42) USP30BCHEGRM5
SCHEMBL6322676 0.83 MEN1 (0.43) STSBCHEMEN1KMT2ASMN1; SMN2
SCHEMBL902929 0.83 BCHE (0.48) USP30BCHE
SCHEMBL7755310 0.79 KMT2A (0.40) STSBCHECNR2MEN1KMT2A
SCHEMBL7900611 0.76 BCHE (0.42) USP30BCHEMEN1KMT2A
SCHEMBL12393913 0.76 GPR119 (0.44) BCHEGRM5
SCHEMBL24565414 0.76 BCHE (0.40) STSBCHE
SCHEMBL8949810 0.76 GPR119 (0.40) BCHEMEN1KMT2ASMN1; SMN2
SCHEMBL12393911 0.75 GPR119 (0.41) USP30BCHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6036766-A SPINNING SOLUTIONS, PAINTS, COATINGS, PRINTING INKS CIBA SPECIALTY CHEMICALS CORPORATION (US) 2000-03-14 US disclosed