Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC3 | Q13507 | 9/20 | 0.69 |
| ▸ | TRPC6 | Q9Y210 | 9/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL807014 | 0.89 | TRPC3 (0.73) | TRPC3TRPC6ALDH1A1NPC1TP53 | |
| SCHEMBL807015 | 0.77 | TRPC3 (1.00) | TRPC3TRPC6MAPTKDRRIPK1 | |
| SCHEMBL23771823 | 0.76 | TRPC3 (1.00) | TRPC3TRPC6ALDH1A1NPC1TP53 | |
| SCHEMBL10087862 | 0.72 | TRPC3 (0.60) | TRPC3TRPC6ALDH1A1NPC1HPGD | |
| SCHEMBL807013 | 0.71 | TRPC3 (1.00) | TRPC3TRPC6ALDH1A1NPC1TP53 | |
| SCHEMBL806599 | 0.71 | TRPC3 (0.58) | TRPC3TRPC6ALDH1A1NPC1HPGD | |
| SCHEMBL807011 | 0.70 | TRPC3 (0.58) | TRPC3TRPC6ALDH1A1NPC1TP53 | |
| SCHEMBL789220 | 0.69 | MAPT (0.53) | TRPC3TRPC6ALDH1A1NPC1HPGD | |
| SCHEMBL10080528 | 0.67 | RAB9A (0.58) | TRPC3TRPC6ALDH1A1NPC1HPGD | |
| SCHEMBL10080531 | 0.66 | TRPC3 (0.58) | TRPC3TRPC6ALDH1A1NPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037349-A2 | COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |