Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.47 |
| ▸ | HCAR3 | P49019 | 10/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8070684 | 1.00 | LMNA (0.49) | LMNASRD5A2HCAR3TSHRCASP6 | |
| SCHEMBL8078533 | 0.92 | SRD5A2 (0.51) | LMNASRD5A2HCAR3TSHRCASP6 | |
| SCHEMBL8695884 | 0.90 | LMNA (0.39) | LMNASRD5A2HCAR3TSHRMAPK1 | |
| SCHEMBL8433598 | 0.88 | VCAM1 (0.46) | LMNASRD5A2MEN1KMT2AERN1 | |
| SCHEMBL8437445 | 0.87 | SRD5A2 (0.47) | LMNASRD5A2HCAR3TSHRCASP6 | |
| SCHEMBL8437651 | 0.86 | SRD5A2 (0.46) | LMNASRD5A2 | |
| SCHEMBL8435101 | 0.79 | VCAM1 (0.50) | LMNASRD5A2MEN1KMT2AERN1 | |
| SCHEMBL8433883 | 0.74 | SRD5A2 (0.47) | LMNASRD5A2 | |
| SCHEMBL8435617 | 0.73 | SRD5A2 (0.46) | LMNASRD5A2 | |
| SCHEMBL8433248 | 0.72 | SRD5A2 (0.59) | LMNASRD5A2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757982-B1 | Biphenylic compounds, process for their preparations and intermediates for this process, their use as 5-alpha-reductase inhibitors and pharmaceutical compositions containing them | HOECHST MARION ROUSSEL INC (FR) | 2000-09-20 | — | — | EP | disclosed |
| EP-0757982-A1 | Biphenylic compounds, process for their preparations and intermediates for this process, their use as 5-alpha-reductase inhibitors and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1997-02-12 | — | — | EP | disclosed |