Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 3/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.52 |
| ▸ | CHKA | P35790 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.50 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.49 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3979002 | 0.95 | SIGMAR1 (0.63) | LSSLMNASIGMAR1ALDH1A1HPGD | |
| SCHEMBL24023496 | 0.86 | CHKA (0.62) | LMNASIGMAR1ALDH1A1PKMHRH3 | |
| SCHEMBL10921447 | 0.84 | SIGMAR1 (0.59) | LSSLMNASIGMAR1ALDH1A1KDM4E | |
| SCHEMBL27739921 | 0.84 | LSS (0.65) | LSSSIGMAR1ALDH1A1KDM4EHRH3 | |
| SCHEMBL32668994 | 0.84 | HTR2A (0.57) | LSSLMNASIGMAR1ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL8804628 | 0.84 | HTR2A (0.60) | LSSLMNASIGMAR1ALDH1A1KDM4E | |
| SCHEMBL27760478 | 0.81 | LSS (0.61) | LSSSIGMAR1ALDH1A1KDM4EHRH3 | |
| SCHEMBL8070873 | 0.81 | PKM (0.56) | LMNASIGMAR1ALDH1A1PKMMEN1 | |
| SCHEMBL3988740 | 0.80 | HTR7 (0.58) | LMNASIGMAR1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL10502663 | 0.80 | SIGMAR1 (0.68) | LSSSIGMAR1ALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046332-A | Methods for the manufacture of cetirizine | TAO YONG (CA) | 2000-04-04 | — | — | US | disclosed |
| WO-1998002425-A1 | METHODS FOR THE MANUFACTURE OF CETIRIZINE | APOTEX INC. (CA) | 1998-01-22 | — | — | WO | disclosed |